Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk)

Gunter G C Kuhnle, Natasha Tasevska, Marleen A H Lentjes, Julian L. Griffin, Matthew A. Sims, Larissa Richardson, Sue M. Aspinall, Angela A. Mulligan, Robert N. Luben, Kay Tee Khaw

    Research output: Contribution to journalArticle

    18 Scopus citations

    Abstract

    Objective The objective of the present study was to investigate associations between sugar intake and overweight using dietary biomarkers in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk). Design Prospective cohort study. Setting EPIC-Norfolk in the UK, recruitment between 1993 and 1997. Subjects Men and women (n 1734) aged 39-77 years. Sucrose intake was assessed using 7 d diet diaries. Baseline spot urine samples were analysed for sucrose by GC-MS. Sucrose concentration adjusted by specific gravity was used as a biomarker for intake. Regression analyses were used to investigate associations between sucrose intake and risk of BMI>25·0 kg/m2 after three years of follow-up. Results After three years of follow-up, mean BMI was 26·8 kg/m2. Self-reported sucrose intake was significantly positively associated with the biomarker. Associations between the biomarker and BMI were positive (β=0·25; 95 % CI 0·08, 0·43), while they were inverse when using self-reported dietary data (β=-1·40; 95 % CI -1·81, -0·99). The age- and sex-adjusted OR for BMI>25·0 kg/m2 in participants in the fifth v. first quintile was 1·54 (95 % CI 1·12, 2·12; P trend=0·003) when using biomarker and 0·56 (95 % CI 0·40, 0·77; P trend<0·001) with self-reported dietary data. Conclusions Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI. Future studies should consider the use of objective biomarkers of sucrose intake.

    Original languageEnglish (US)
    Pages (from-to)2815-2824
    Number of pages10
    JournalPublic Health Nutrition
    Volume18
    Issue number15
    DOIs
    StatePublished - Nov 14 2015

    Keywords

    • Biomarker
    • Obesity
    • Sugar

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics
    • Public Health, Environmental and Occupational Health

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  • Cite this

    Kuhnle, G. G. C., Tasevska, N., Lentjes, M. A. H., Griffin, J. L., Sims, M. A., Richardson, L., Aspinall, S. M., Mulligan, A. A., Luben, R. N., & Khaw, K. T. (2015). Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk). Public Health Nutrition, 18(15), 2815-2824. https://doi.org/10.1017/S1368980015000300