Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population

J. D. Lindenau, L. S P Guimarães, Ana Hurtado, Kim Hill, L. T. Tsuneto, F. M. Salzano, M. L. Petzl-Erler, M. H. Hutz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1* 04, DQA1* 03 and DQB1* 03:02 were associated with TST response in this population.

Original languageEnglish (US)
Pages (from-to)479-483
Number of pages5
JournalTissue antigens
Volume84
Issue number5
DOIs
StatePublished - Nov 1 2014

Keywords

  • Amerindians
  • Anergy
  • Human leukocyte antigen
  • Tuberculin skin test response response
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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