Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population

J. D. Lindenau; L. S P Guimarães; Ana Hurtado; Kim Hill; L. T. Tsuneto; F. M. Salzano; M. L. Petzl-Erler; M. H. Hutz

doi:10.1111/tan.12451

Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population

J. D. Lindenau, L. S P Guimarães, Ana Hurtado, Kim Hill, L. T. Tsuneto, F. M. Salzano, M. L. Petzl-Erler, M. H. Hutz

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1* 04, DQA1* 03 and DQB1* 03:02 were associated with TST response in this population.

Original language	English (US)
Pages (from-to)	479-483
Number of pages	5
Journal	Tissue antigens
Volume	84
Issue number	5
DOIs	https://doi.org/10.1111/tan.12451
State	Published - Nov 1 2014

Keywords

Amerindians
Anergy
Human leukocyte antigen
Tuberculin skin test response response
Tuberculosis

ASJC Scopus subject areas

Genetics
Biochemistry
Immunology and Allergy
Immunology

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10.1111/tan.12451

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@article{a5d3da9fd41a49d28be94bb6a3d6b398,

title = "Association between HLA-DR4 haplotypes and tuberculin skin test response in the Ach{\'e} population",

abstract = "The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Ach{\'e} population. Poisson Regression was employed to assess risk genotypes. DRB1* 04, DQA1* 03 and DQB1* 03:02 were associated with TST response in this population.",

keywords = "Amerindians, Anergy, Human leukocyte antigen, Tuberculin skin test response response, Tuberculosis",

author = "Lindenau, {J. D.} and Guimar{\~a}es, {L. S P} and Ana Hurtado and Kim Hill and Tsuneto, {L. T.} and Salzano, {F. M.} and Petzl-Erler, {M. L.} and Hutz, {M. H.}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

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doi = "10.1111/tan.12451",

language = "English (US)",

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AU - Lindenau, J. D.

AU - Guimarães, L. S P

AU - Hurtado, Ana

AU - Hill, Kim

AU - Tsuneto, L. T.

AU - Salzano, F. M.

AU - Petzl-Erler, M. L.

AU - Hutz, M. H.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1* 04, DQA1* 03 and DQB1* 03:02 were associated with TST response in this population.

AB - The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1* 04, DQA1* 03 and DQB1* 03:02 were associated with TST response in this population.

KW - Amerindians

KW - Anergy

KW - Human leukocyte antigen

KW - Tuberculin skin test response response

KW - Tuberculosis

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ER -

Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population

Abstract

Keywords

ASJC Scopus subject areas

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