Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population

J. D. Lindenau, L. S P Guimarães, Ana Hurtado, Kim Hill, L. T. Tsuneto, F. M. Salzano, M. L. Petzl-Erler, M. H. Hutz

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1*04, DQA1*03 and DQB1*03:02 were associated with TST response in this population.

    Original languageEnglish (US)
    Pages (from-to)479-483
    Number of pages5
    JournalTissue Antigens
    Volume84
    Issue number5
    DOIs
    StatePublished - Nov 1 2014

    Fingerprint

    Tuberculin Test
    HLA Antigens
    Skin Tests
    Haplotypes
    Tuberculosis
    Genotype
    Population
    South America
    Alleles
    Genes

    Keywords

    • Amerindians
    • anergy
    • human leukocyte antigen
    • tuberculin skin test response response
    • tuberculosis

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Lindenau, J. D., Guimarães, L. S. P., Hurtado, A., Hill, K., Tsuneto, L. T., Salzano, F. M., ... Hutz, M. H. (2014). Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population. Tissue Antigens, 84(5), 479-483. https://doi.org/10.1111/tan.12451

    Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population. / Lindenau, J. D.; Guimarães, L. S P; Hurtado, Ana; Hill, Kim; Tsuneto, L. T.; Salzano, F. M.; Petzl-Erler, M. L.; Hutz, M. H.

    In: Tissue Antigens, Vol. 84, No. 5, 01.11.2014, p. 479-483.

    Research output: Contribution to journalArticle

    Lindenau, JD, Guimarães, LSP, Hurtado, A, Hill, K, Tsuneto, LT, Salzano, FM, Petzl-Erler, ML & Hutz, MH 2014, 'Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population' Tissue Antigens, vol. 84, no. 5, pp. 479-483. https://doi.org/10.1111/tan.12451
    Lindenau, J. D. ; Guimarães, L. S P ; Hurtado, Ana ; Hill, Kim ; Tsuneto, L. T. ; Salzano, F. M. ; Petzl-Erler, M. L. ; Hutz, M. H. / Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population. In: Tissue Antigens. 2014 ; Vol. 84, No. 5. pp. 479-483.
    @article{a5d3da9fd41a49d28be94bb6a3d6b398,
    title = "Association between HLA-DR4 haplotypes and tuberculin skin test response in the Ach{\'e} population",
    abstract = "The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Ach{\'e} population. Poisson Regression was employed to assess risk genotypes. DRB1*04, DQA1*03 and DQB1*03:02 were associated with TST response in this population.",
    keywords = "Amerindians, anergy, human leukocyte antigen, tuberculin skin test response response, tuberculosis",
    author = "Lindenau, {J. D.} and Guimar{\~a}es, {L. S P} and Ana Hurtado and Kim Hill and Tsuneto, {L. T.} and Salzano, {F. M.} and Petzl-Erler, {M. L.} and Hutz, {M. H.}",
    year = "2014",
    month = "11",
    day = "1",
    doi = "10.1111/tan.12451",
    language = "English (US)",
    volume = "84",
    pages = "479--483",
    journal = "HLA",
    issn = "2059-2302",
    publisher = "Wiley-Blackwell",
    number = "5",

    }

    TY - JOUR

    T1 - Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population

    AU - Lindenau, J. D.

    AU - Guimarães, L. S P

    AU - Hurtado, Ana

    AU - Hill, Kim

    AU - Tsuneto, L. T.

    AU - Salzano, F. M.

    AU - Petzl-Erler, M. L.

    AU - Hutz, M. H.

    PY - 2014/11/1

    Y1 - 2014/11/1

    N2 - The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1*04, DQA1*03 and DQB1*03:02 were associated with TST response in this population.

    AB - The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1*04, DQA1*03 and DQB1*03:02 were associated with TST response in this population.

    KW - Amerindians

    KW - anergy

    KW - human leukocyte antigen

    KW - tuberculin skin test response response

    KW - tuberculosis

    UR - http://www.scopus.com/inward/record.url?scp=84923117672&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84923117672&partnerID=8YFLogxK

    U2 - 10.1111/tan.12451

    DO - 10.1111/tan.12451

    M3 - Article

    VL - 84

    SP - 479

    EP - 483

    JO - HLA

    JF - HLA

    SN - 2059-2302

    IS - 5

    ER -