Association between circulating Vitamin D metabolites and fecal bile acid concentrations

Elizabeth T. Jacobs, Mark R. Haussler, David S. Alberts, Lindsay N. Kohler, Peter Lance, María Elena Martínez, Denise J. Roe, Peter Jurutka

Research output: Contribution to journalArticle

Abstract

Although hydrophobic bile acids have been demonstrated to exhibit cytotoxic and carcinogenic effects in the colorectum, ursodeoxycholic acid (UDCA) has been investigated as a potential chemopreventive agent. Vitamin D has been shown to play a role in both bile acid metabolism and in the development of colorectal neoplasia. Using a cross-sectional design, we sought to determine whether baseline circulating concentrations of the Vitamin D metabolites 25(OH)D and 1,25(OH)2D were associated with baseline fecal bile acid concentrations in a trial of UDCA for the prevention of colorectal adenoma recurrence. We also prospectively evaluated whether Vitamin D metabolite concentrations modified the effect of UDCA on adenoma recurrence. After adjustment for age, sex, BMI, physical activity, and calcium intake, adequate concentrations of 25(OH)D (30 ng/mL) were statistically significantly associated with reduced odds for high levels of total [OR, 0.61; 95% confidence interval (CI), 0.38-0.97], and primary (OR, 0.61; 95% CI, 0.38-0.96) bile acids, as well as individually with chenodeoxycholic acid (OR, 0.39; 95% CI, 0.24-0.63) and cholic acid (OR, 0.56; 95% CI, 0.36-0.90). No significant associations were observed for 1,25(OH)2D and high versus low fecal bile acid concentrations. In addition, neither 25(OH)D nor 1,25 (OH)2D modified the effect of UDCA on colorectal adenoma recurrence. In conclusion, this is the first study to demonstrate an inverse relationship between circulating levels of 25(OH)D and primary fecal bile acid concentrations. These results support prior data demonstrating that Vitamin D plays a key role in bile acid metabolism, and suggest a potential mechanism of action for 25(OH)D in colorectal cancer prevention.

Original languageEnglish (US)
Pages (from-to)589-597
Number of pages9
JournalCancer Prevention Research
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Bile Acids and Salts
Vitamin D
Ursodeoxycholic Acid
Adenoma
Confidence Intervals
Recurrence
Chenodeoxycholic Acid
Cholic Acid
Action Potentials
Colorectal Neoplasms
Calcium
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Jacobs, E. T., Haussler, M. R., Alberts, D. S., Kohler, L. N., Lance, P., Martínez, M. E., ... Jurutka, P. (2016). Association between circulating Vitamin D metabolites and fecal bile acid concentrations. Cancer Prevention Research, 9(7), 589-597. https://doi.org/10.1158/1940-6207.CAPR-16-0033

Association between circulating Vitamin D metabolites and fecal bile acid concentrations. / Jacobs, Elizabeth T.; Haussler, Mark R.; Alberts, David S.; Kohler, Lindsay N.; Lance, Peter; Martínez, María Elena; Roe, Denise J.; Jurutka, Peter.

In: Cancer Prevention Research, Vol. 9, No. 7, 01.07.2016, p. 589-597.

Research output: Contribution to journalArticle

Jacobs, ET, Haussler, MR, Alberts, DS, Kohler, LN, Lance, P, Martínez, ME, Roe, DJ & Jurutka, P 2016, 'Association between circulating Vitamin D metabolites and fecal bile acid concentrations', Cancer Prevention Research, vol. 9, no. 7, pp. 589-597. https://doi.org/10.1158/1940-6207.CAPR-16-0033
Jacobs, Elizabeth T. ; Haussler, Mark R. ; Alberts, David S. ; Kohler, Lindsay N. ; Lance, Peter ; Martínez, María Elena ; Roe, Denise J. ; Jurutka, Peter. / Association between circulating Vitamin D metabolites and fecal bile acid concentrations. In: Cancer Prevention Research. 2016 ; Vol. 9, No. 7. pp. 589-597.
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