Association between alleles of the transforming growth factor-alpha locus and the occurrence of cleft lip

R. Sassani, S. P. Bartlett, H. Feng, A. Goldner-Sauve, A. K. Haq, Kenneth Buetow, D. L. Gasser

Research output: Contribution to journalArticle

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Abstract

DNA samples from 100 patients with cleft lip with or without cleft palate (CL/P) were compared with those of 98 unaffected control individuals with respect to transforming growth factor alpha (TGFA) genotypes. Among the Caucasians in this population (83 CL/P, 84 controls), there was a significant difference in the restriction fragment length polymorphisms (RFLPs) observed after digestion with TaqI (χ2 = 4.68, P = 0.03). The frequency of the C2 allele in the Caucasian CL/P population was 0.169, whereas that in the control group was 0.089. When the data for Caucasians, African-Americans, and Asians were examined jointly, the χ2 value for the pooled sample was 5.08 (P = 0.02). This confirms the hypothesis of Ardinger et al. [1989, Am J Hum Genet, 45:348-353] that TFGA itself or a closely linked gene contributes to the development of CL/P in humans.

Original languageEnglish (US)
Pages (from-to)565-569
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume45
Issue number5
StatePublished - 1993
Externally publishedYes

Fingerprint

Transforming Growth Factor alpha
Cleft Lip
Cleft Palate
Alleles
Viverridae
Gene Frequency
Restriction Fragment Length Polymorphisms
African Americans
Population
Digestion
Genotype
Control Groups
DNA
Genes

Keywords

  • CL/P
  • cleft lip
  • TFGA

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Sassani, R., Bartlett, S. P., Feng, H., Goldner-Sauve, A., Haq, A. K., Buetow, K., & Gasser, D. L. (1993). Association between alleles of the transforming growth factor-alpha locus and the occurrence of cleft lip. American Journal of Medical Genetics, 45(5), 565-569.

Association between alleles of the transforming growth factor-alpha locus and the occurrence of cleft lip. / Sassani, R.; Bartlett, S. P.; Feng, H.; Goldner-Sauve, A.; Haq, A. K.; Buetow, Kenneth; Gasser, D. L.

In: American Journal of Medical Genetics, Vol. 45, No. 5, 1993, p. 565-569.

Research output: Contribution to journalArticle

Sassani, R, Bartlett, SP, Feng, H, Goldner-Sauve, A, Haq, AK, Buetow, K & Gasser, DL 1993, 'Association between alleles of the transforming growth factor-alpha locus and the occurrence of cleft lip', American Journal of Medical Genetics, vol. 45, no. 5, pp. 565-569.
Sassani, R. ; Bartlett, S. P. ; Feng, H. ; Goldner-Sauve, A. ; Haq, A. K. ; Buetow, Kenneth ; Gasser, D. L. / Association between alleles of the transforming growth factor-alpha locus and the occurrence of cleft lip. In: American Journal of Medical Genetics. 1993 ; Vol. 45, No. 5. pp. 565-569.
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