TY - JOUR
T1 - Assessment of persistent, bioaccumulative and toxic organic environmental pollutants in liver and adipose tissue of alzheimer’s disease patients and age-matched controls
AU - Manivannan, Bhagyashree
AU - Yegambaram, Manivannan
AU - Supowit, Samuel
AU - Beach, Thomas G.
AU - Halden, Rolf U.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Lifetime exposure to environmental (neuro) toxicants may contribute to the pathogenesis of Alzheimer’s Disease (AD). Since many contaminants do not cross the blood-brain barrier, brain tissue alone cannot serve to assess the spectrum of environmental exposures. Methods: We used liquid and gas chromatography tandem mass spectrometry to monitor, in postmortem liver and adipose tissues of AD patients and age-matched controls, the occurrence and concentrations of 11 environmental contaminants. Results: Seven toxicants were detected at 100% frequency: P,p’-DDE, dieldrin, triclosan, methylparaben, bisphenol A, fipronil and tetrabromobisphenol A (TBBPA). Intra-individual, tissuedependent differences were detected for triclosan, methylparaben, fipronil and TBBPA. High concentrations of p,p’-DDE and dieldrin were observed in adipose tissue when compared to liver values for both AD cases and controls. Conclusion: This study provides vital data on organ-specific human body burdens to select analytes and demonstrate the feasibility of analyzing small sample quantities for toxicants suspected to constitute AD risk factors.
AB - Background: Lifetime exposure to environmental (neuro) toxicants may contribute to the pathogenesis of Alzheimer’s Disease (AD). Since many contaminants do not cross the blood-brain barrier, brain tissue alone cannot serve to assess the spectrum of environmental exposures. Methods: We used liquid and gas chromatography tandem mass spectrometry to monitor, in postmortem liver and adipose tissues of AD patients and age-matched controls, the occurrence and concentrations of 11 environmental contaminants. Results: Seven toxicants were detected at 100% frequency: P,p’-DDE, dieldrin, triclosan, methylparaben, bisphenol A, fipronil and tetrabromobisphenol A (TBBPA). Intra-individual, tissuedependent differences were detected for triclosan, methylparaben, fipronil and TBBPA. High concentrations of p,p’-DDE and dieldrin were observed in adipose tissue when compared to liver values for both AD cases and controls. Conclusion: This study provides vital data on organ-specific human body burdens to select analytes and demonstrate the feasibility of analyzing small sample quantities for toxicants suspected to constitute AD risk factors.
KW - Adipose tissue
KW - Alzheimer’s disease
KW - Contaminants
KW - Environmental (neuro) toxicants
KW - Liquid and gas chromatography tandem mass spectrometry
KW - Liver
KW - Pollutants
UR - http://www.scopus.com/inward/record.url?scp=85076586036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076586036&partnerID=8YFLogxK
U2 - 10.2174/1567205016666191010114744
DO - 10.2174/1567205016666191010114744
M3 - Article
C2 - 31660829
AN - SCOPUS:85076586036
SN - 1567-2050
VL - 16
SP - 1039
EP - 1049
JO - Current Alzheimer research
JF - Current Alzheimer research
IS - 11
ER -