Assessment of diagnostic tests when disease verification is subject to selection bias.

C. B. Begg, R. A. Greenes

Research output: Contribution to journalArticle

524 Scopus citations

Abstract

In the assessment of the statistical properties of a diagnostic test, for example the sensitivity and specificity of the test, it is common to derive estimates from a sample limited to those cases for whom subsequent definitive disease verification is obtained. Omission of nonverified cases can seriously bias the estimates. In order to adjust the estimates it is necessary to make assumptions about the mechanism for selecting cases for verification. Methods for making the necessary adjustments can then be derived.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalBiometrics
Volume39
Issue number1
DOIs
StatePublished - Mar 1983
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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