Assessment of diagnostic tests when disease verification is subject to selection bias.

C. B. Begg; R. A. Greenes

doi:10.2307/2530820

Assessment of diagnostic tests when disease verification is subject to selection bias.

C. B. Begg, R. A. Greenes

Research output: Contribution to journal › Article › peer-review

578 Scopus citations

Abstract

In the assessment of the statistical properties of a diagnostic test, for example the sensitivity and specificity of the test, it is common to derive estimates from a sample limited to those cases for whom subsequent definitive disease verification is obtained. Omission of nonverified cases can seriously bias the estimates. In order to adjust the estimates it is necessary to make assumptions about the mechanism for selecting cases for verification. Methods for making the necessary adjustments can then be derived.

Original language	English (US)
Pages (from-to)	207-215
Number of pages	9
Journal	Biometrics
Volume	39
Issue number	1
DOIs	https://doi.org/10.2307/2530820
State	Published - Mar 1983
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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10.2307/2530820

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title = "Assessment of diagnostic tests when disease verification is subject to selection bias.",

abstract = "In the assessment of the statistical properties of a diagnostic test, for example the sensitivity and specificity of the test, it is common to derive estimates from a sample limited to those cases for whom subsequent definitive disease verification is obtained. Omission of nonverified cases can seriously bias the estimates. In order to adjust the estimates it is necessary to make assumptions about the mechanism for selecting cases for verification. Methods for making the necessary adjustments can then be derived.",

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Assessment of diagnostic tests when disease verification is subject to selection bias.

Abstract

ASJC Scopus subject areas

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