TY - JOUR
T1 - Assessing the effect of natural selection in malaria parasites
AU - Escalante, Ananias A.
AU - Cornejo, Omar E.
AU - Rojas, Ascanio
AU - Udhayakumar, Venkatachalam
AU - Lal, Altaf A.
N1 - Funding Information:
A.A.E. is supported by a grant from The National Institutes of Health (R01 GM60740). O.E.C. and A.R. are supported by fellowships of FONACIT-Venezuela. We thank R. Steketee, A. McCollum and anonymous reviewers for helpful comments.
PY - 2004/8/1
Y1 - 2004/8/1
N2 - There are few concepts that have been used across disciplines; one of them is natural selection. The impact that this process has on parasite genetic diversity is reviewed here by discussing examples on drug resistance and vaccine antigens. Emphasis is made on how mechanisms need to be addressed rather than associations, and how such investigations were out of reach of biomedical researchers only a decade ago.
AB - There are few concepts that have been used across disciplines; one of them is natural selection. The impact that this process has on parasite genetic diversity is reviewed here by discussing examples on drug resistance and vaccine antigens. Emphasis is made on how mechanisms need to be addressed rather than associations, and how such investigations were out of reach of biomedical researchers only a decade ago.
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U2 - 10.1016/j.pt.2004.06.002
DO - 10.1016/j.pt.2004.06.002
M3 - Review article
C2 - 15246323
AN - SCOPUS:3142740248
SN - 1471-4922
VL - 20
SP - 388
EP - 395
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 8
ER -