Assembly of DNA rotaxanes for AFM based sequencing

Q. Spadola, S. Qamar, L. Lin, B. Ashcroft, Peiming Zhang, Stuart Lindsay

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Development of DNA sequencing technologies has been fueled by the desire to unlock the genetic information stored inside of genomes. This information can help fields as varied as molecular medicine, bioarcheology, forensics, and environmental science. The challenge is to establish a method that is more cost effective and faster than the ones currently available. Our technique takes advantage of the atomic force microscope's (AFM) ability to detect piconewton scale forces in order to read off sequencing information based on the interaction of nucleotides with a cyclodextrin.

Original languageEnglish (US)
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages240-243
Number of pages4
StatePublished - Dec 8 2006
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: May 7 2006May 11 2006

Publication series

Name2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Volume2

Other

Other2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
CountryUnited States
CityBoston, MA
Period5/7/065/11/06

Keywords

  • AFM
  • DNA
  • Rotaxanes
  • Sequencing

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Spadola, Q., Qamar, S., Lin, L., Ashcroft, B., Zhang, P., & Lindsay, S. (2006). Assembly of DNA rotaxanes for AFM based sequencing. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (pp. 240-243). (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings; Vol. 2).