Aptamer-directed self-assembly of protein arrays on a DNA nanostructure

Yan Liu, Chenxiang Lin, Hanying Li, Hao Yan

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


(Chemical Equation Presented) Lined up nicely: The self-assembly of proteins on rationally designed nanostructures into periodic linear arrays has been demonstrated. Triple-crossover DNA tiles 1 containing an aptamer sequence (AS) to which thrombin specifically binds can form linear arrays 2. These direct the ultimate positioning of thrombin proteins (green spheres) in 3. This system should facilitate the construction of other such programmable nanoscale protein arrays.

Original languageEnglish (US)
Pages (from-to)4333-4338
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number28
StatePublished - Jul 11 2005


  • DNA structures
  • Nanostructures
  • Protein arrays
  • Scanning probe microscopy
  • Self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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