Aptamer-directed self-assembly of protein arrays on a DNA nanostructure

Yan Liu; Chenxiang Lin; Hanying Li; Hao Yan

doi:10.1002/anie.200501089

Aptamer-directed self-assembly of protein arrays on a DNA nanostructure

Yan Liu, Chenxiang Lin, Hanying Li, Hao Yan

Research output: Contribution to journal › Article › peer-review

167 Scopus citations

Abstract

(Chemical Equation Presented) Lined up nicely: The self-assembly of proteins on rationally designed nanostructures into periodic linear arrays has been demonstrated. Triple-crossover DNA tiles 1 containing an aptamer sequence (AS) to which thrombin specifically binds can form linear arrays 2. These direct the ultimate positioning of thrombin proteins (green spheres) in 3. This system should facilitate the construction of other such programmable nanoscale protein arrays.

Original language	English (US)
Pages (from-to)	4333-4338
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	28
DOIs	https://doi.org/10.1002/anie.200501089
State	Published - Jul 11 2005

Keywords

DNA structures
Nanostructures
Protein arrays
Scanning probe microscopy
Self-assembly

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200501089

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