Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

Mohammad R. Ebrahimkhani, Carissa L. Young, Douglas A. Lauffenburger, Linda G. Griffith, Jeffrey T. Borenstein

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science.

Original languageEnglish (US)
Pages (from-to)754-762
Number of pages9
JournalDrug discovery today
Volume19
Issue number6
DOIs
StatePublished - Jun 2014

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Ebrahimkhani, M. R., Young, C. L., Lauffenburger, D. A., Griffith, L. G., & Borenstein, J. T. (2014). Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Drug discovery today, 19(6), 754-762. https://doi.org/10.1016/j.drudis.2014.04.017