TY - JOUR
T1 - Approaches to in vitro tissue regeneration with application for human disease modeling and drug development
AU - Ebrahimkhani, Mohammad R.
AU - Young, Carissa L.
AU - Lauffenburger, Douglas A.
AU - Griffith, Linda G.
AU - Borenstein, Jeffrey T.
N1 - Funding Information:
This work was made possible by Grant Number 5R01EB010246-02 from the NIH NIBIB, Grant Number 1UH2TR000496 from the NIH NCATS and Cooperative Agreement Number W911NF-12-2-0039 from DARPA.
PY - 2014/6
Y1 - 2014/6
N2 - Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science.
AB - Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science.
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U2 - 10.1016/j.drudis.2014.04.017
DO - 10.1016/j.drudis.2014.04.017
M3 - Review article
C2 - 24793141
AN - SCOPUS:84902103618
SN - 1359-6446
VL - 19
SP - 754
EP - 762
JO - Drug discovery today
JF - Drug discovery today
IS - 6
ER -