Approaches for identifying targets of positive selection

Jeffrey Jensen, Alex Wong, Charles F. Aquadro

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

Despite significant advancements in both empirical and theoretical population genetics throughout the past century, fundamental questions about the evolutionary forces that shape genomic diversity remain unresolved. Perhaps foremost among these are the strength and frequency of adaptive evolution. To quantify these parameters, statistical tools are needed that are capable of effectively identifying targets of positive selection throughout the genome in an unbiased manner, and functional approaches are needed that are capable of connecting these identified genotypes with the resulting adaptively significant phenotypes. Here we review recent advancements in both statistical and empirical methodology, and discuss important challenges and opportunities that remain as researchers continue to uncouple the relative importance of stochastic and deterministic factors in the evolution of natural populations.

Original languageEnglish (US)
Pages (from-to)568-577
Number of pages10
JournalTrends in Genetics
Volume23
Issue number11
DOIs
StatePublished - Nov 2007
Externally publishedYes

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Population Genetics
Genotype
Research Personnel
Genome
Phenotype
Population

ASJC Scopus subject areas

  • Genetics

Cite this

Approaches for identifying targets of positive selection. / Jensen, Jeffrey; Wong, Alex; Aquadro, Charles F.

In: Trends in Genetics, Vol. 23, No. 11, 11.2007, p. 568-577.

Research output: Contribution to journalReview article

Jensen, Jeffrey ; Wong, Alex ; Aquadro, Charles F. / Approaches for identifying targets of positive selection. In: Trends in Genetics. 2007 ; Vol. 23, No. 11. pp. 568-577.
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