Application of flexible OLED display technology for electro-optical stimulation and/or silencing of neural activity

Joseph T. Smith, Barry O'Brien, Yong Kyun Lee, Edward J. Bawolek, Jennifer Blain Christen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This paper presents a new biophotonic application for large-area, high-resolution, flexible organic light-emitting diode (OLED) display technology currently used to manufacture low-cost color flexible displays on plastic substrates. The new concept uses a fully addressable high resolution flexible OLED pixel array on a thin, mechanically compliant biocompatible plastic substrate to selectively stimulate and/or silence small groups of neurons on either the cortical surface or, alternatively, within the deep brain. Optical measurements from a 455 nm blue flexible OLED test structure demonstrated the ability to emit 1 mW/mm2 of instantaneous light intensity using a 13 V, 20 Hz pulse, which meets the minimum reported intensity at $sim450 nm to induce optical stimulation in genetically modified neural tissue. Biocompatibility was successfully demonstrated by the ability to grow human epithelial cells on the surface of a full TFT process flow plastic flexible display substrate. Additionally, a new active matrix array display architecture was designed to support pulsed mode OLED operation. These preliminary results demonstrate the initial viability of extending flexible plastic substrate OLED display technology to the development of large-area, high-resolution emissive active matrix arrays for chronic optogenetic applications.

Original languageEnglish (US)
Article number6748913
Pages (from-to)514-520
Number of pages7
JournalIEEE/OSA Journal of Display Technology
Volume10
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Organic light emitting diodes (OLED)
stimulation
light emitting diodes
Display devices
Flexible displays
plastics
Substrates
Plastics
high resolution
plastic flow
biocompatibility
matrices
Plastic flow
neurons
Biocompatibility
optical measurement
viability
luminous intensity
Neurons
brain

Keywords

  • Flexible electronics
  • optogenetics
  • organic light emitting diodes (OLEDs)
  • thin-film transistors (TFTs)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Application of flexible OLED display technology for electro-optical stimulation and/or silencing of neural activity. / Smith, Joseph T.; O'Brien, Barry; Lee, Yong Kyun; Bawolek, Edward J.; Blain Christen, Jennifer.

In: IEEE/OSA Journal of Display Technology, Vol. 10, No. 6, 6748913, 2014, p. 514-520.

Research output: Contribution to journalArticle

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