Application of flat panel OLED display technology for the point-of-care detection of circulating cancer biomarkers

Benjamin A. Katchman, Joseph T. Smith, Uwadiae Obahiagbon, Sailaja Kesiraju, Yong Kyun Lee, Barry O'Brien, Korhan Kaftanoglu, Jennifer Blain Christen, Karen Anderson

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Point-of-care molecular diagnostics can provide efficient and cost-effective medical care, and they have the potential to fundamentally change our approach to global health. However, most existing approaches are not scalable to include multiple biomarkers. As a solution, we have combined commercial flat panel OLED display technology with protein microarray technology to enable high-density fluorescent, programmable, multiplexed biorecognition in a compact and disposable configuration with clinical-level sensitivity. Our approach leverages advances in commercial display technology to reduce pre-functionalized biosensor substrate costs to pennies per cm 2. Here, we demonstrate quantitative detection of IgG antibodies to multiple viral antigens in patient serum samples with detection limits for human IgG in the 10 pg/mL range. We also demonstrate multiplexed detection of antibodies to the HPV16 proteins E2, E6, and E7, which are circulating biomarkers for cervical as well as head and neck cancers.

Original languageEnglish (US)
Article number29057
JournalScientific reports
Volume6
DOIs
StatePublished - Jul 4 2016

ASJC Scopus subject areas

  • General

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