Application of embryonic and adult zebrafish for nanotoxicity assessment

Jiangxin Wang, Xiaoshan Zhu, Yongsheng Chen, Yung Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

As an emerging model for toxicological studies, zebrafish has been explored for nanotoxicity assessment. In addition to endpoint examination of embryo/fish mortality and/or developmental disorders, molecular analyses of differential gene expression have also been employed to evaluate toxic effects associated with the exposure to nanomaterials. Here, we describe zebrafish-based assays, including both embryo and adult, for evaluation of nanotoxicity caused by metal oxide nanoparticles (NPs), in particular, zinc oxide (ZnO) and titanium oxide (TiO<inf>2</inf>) nanoparticles.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages317-329
Number of pages13
Volume926
ISBN (Print)9781627030014
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume926
ISSN (Print)10643745

Fingerprint

Zebrafish
Embryonic Structures
Metal Nanoparticles
Zinc Oxide
Nanostructures
Poisons
Nanoparticles
Toxicology
Oxides
Fishes
Gene Expression
Mortality
titanium dioxide

Keywords

  • Acute
  • Chronic toxicity
  • Microarray
  • Nanoparticles
  • Nanotoxicology
  • Zebrafish embryos

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Wang, J., Zhu, X., Chen, Y., & Chang, Y. (2012). Application of embryonic and adult zebrafish for nanotoxicity assessment. In Methods in Molecular Biology (Vol. 926, pp. 317-329). (Methods in Molecular Biology; Vol. 926). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-2-1_20

Application of embryonic and adult zebrafish for nanotoxicity assessment. / Wang, Jiangxin; Zhu, Xiaoshan; Chen, Yongsheng; Chang, Yung.

Methods in Molecular Biology. Vol. 926 Humana Press Inc., 2012. p. 317-329 (Methods in Molecular Biology; Vol. 926).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wang, J, Zhu, X, Chen, Y & Chang, Y 2012, Application of embryonic and adult zebrafish for nanotoxicity assessment. in Methods in Molecular Biology. vol. 926, Methods in Molecular Biology, vol. 926, Humana Press Inc., pp. 317-329. https://doi.org/10.1007/978-1-62703-2-1_20
Wang J, Zhu X, Chen Y, Chang Y. Application of embryonic and adult zebrafish for nanotoxicity assessment. In Methods in Molecular Biology. Vol. 926. Humana Press Inc. 2012. p. 317-329. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-62703-2-1_20
Wang, Jiangxin ; Zhu, Xiaoshan ; Chen, Yongsheng ; Chang, Yung. / Application of embryonic and adult zebrafish for nanotoxicity assessment. Methods in Molecular Biology. Vol. 926 Humana Press Inc., 2012. pp. 317-329 (Methods in Molecular Biology).
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