Apoptosis: An innate immune response to virus infection

Helen Everett, Grant McFadden

Research output: Contribution to journalReview article

294 Scopus citations


Viruses can induce apoptosis of infected cells either directly, to assist virus dissemination, or by inadvertently triggering cellular sensors that initiate cell death. Cellular checkpoints that can function as 'alarm bells' to transmit pro- apoptotic signals in response to virus infections include death receptors, protein kinase R, mitochondrial membrane potential, p53 and the endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalTrends in microbiology
Issue number4
StatePublished - Apr 1 1999


ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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