Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea

Carol M. Baldwin, Richard R. Bootzin, Dawn C. Schwenke, Stuart F. Quan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlying mechanism(s) for the cognitive deficits and CVD in OSA. A number of studies have suggested that increased levels of oxidative stress and/or antioxidant deficiencies may also be risk factors in cognitive decline and CVD. The influence of antioxidant nutrients and supplements, such as Vitamins B6, B12, C, E, folic acid, alpha-lipoic acid and Coenzyme Q10 on cognitive decline and CVD have been investigated. The influence of antioxidant nutrients or supplements on OSA remains to be investigated. Even if dietary or supplemental antioxidants do not prove to be effective therapies for OSA, dietary assessment and prescription to increase dietary intake of neuro- and cardio-protective nutrients may make it possible to reduce some of the cognitive and cardiovascular sequelae associated with OSA.

Original languageEnglish (US)
Pages (from-to)459-476
Number of pages18
JournalSleep Medicine Reviews
Volume9
Issue number6
DOIs
StatePublished - Dec 2005

Fingerprint

Obstructive Sleep Apnea
Cardiovascular Diseases
Antioxidants
Food
coenzyme Q10
Thioctic Acid
Vitamin B 6
Vitamin B 12
Folic Acid
Free Radicals
Prescriptions
Cognitive Dysfunction
Reactive Oxygen Species
Oxidative Stress
Cytokines

Keywords

  • Alpha-lipoic acid
  • Antioxidants
  • Cardiovascular disease
  • Coenzyme Q
  • Cognitive deficits
  • Cytokines
  • Homocysteine
  • Nutrient intake
  • Obstructive sleep apnea
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Dentistry(all)
  • Ophthalmology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea. / Baldwin, Carol M.; Bootzin, Richard R.; Schwenke, Dawn C.; Quan, Stuart F.

In: Sleep Medicine Reviews, Vol. 9, No. 6, 12.2005, p. 459-476.

Research output: Contribution to journalArticle

Baldwin, Carol M. ; Bootzin, Richard R. ; Schwenke, Dawn C. ; Quan, Stuart F. / Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea. In: Sleep Medicine Reviews. 2005 ; Vol. 9, No. 6. pp. 459-476.
@article{98437bfbbb1b4c6685b92d668b7346c6,
title = "Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea",
abstract = "Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlying mechanism(s) for the cognitive deficits and CVD in OSA. A number of studies have suggested that increased levels of oxidative stress and/or antioxidant deficiencies may also be risk factors in cognitive decline and CVD. The influence of antioxidant nutrients and supplements, such as Vitamins B6, B12, C, E, folic acid, alpha-lipoic acid and Coenzyme Q10 on cognitive decline and CVD have been investigated. The influence of antioxidant nutrients or supplements on OSA remains to be investigated. Even if dietary or supplemental antioxidants do not prove to be effective therapies for OSA, dietary assessment and prescription to increase dietary intake of neuro- and cardio-protective nutrients may make it possible to reduce some of the cognitive and cardiovascular sequelae associated with OSA.",
keywords = "Alpha-lipoic acid, Antioxidants, Cardiovascular disease, Coenzyme Q, Cognitive deficits, Cytokines, Homocysteine, Nutrient intake, Obstructive sleep apnea, Oxidative stress",
author = "Baldwin, {Carol M.} and Bootzin, {Richard R.} and Schwenke, {Dawn C.} and Quan, {Stuart F.}",
year = "2005",
month = "12",
doi = "10.1016/j.smrv.2005.04.004",
language = "English (US)",
volume = "9",
pages = "459--476",
journal = "Sleep Medicine Reviews",
issn = "1087-0792",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea

AU - Baldwin, Carol M.

AU - Bootzin, Richard R.

AU - Schwenke, Dawn C.

AU - Quan, Stuart F.

PY - 2005/12

Y1 - 2005/12

N2 - Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlying mechanism(s) for the cognitive deficits and CVD in OSA. A number of studies have suggested that increased levels of oxidative stress and/or antioxidant deficiencies may also be risk factors in cognitive decline and CVD. The influence of antioxidant nutrients and supplements, such as Vitamins B6, B12, C, E, folic acid, alpha-lipoic acid and Coenzyme Q10 on cognitive decline and CVD have been investigated. The influence of antioxidant nutrients or supplements on OSA remains to be investigated. Even if dietary or supplemental antioxidants do not prove to be effective therapies for OSA, dietary assessment and prescription to increase dietary intake of neuro- and cardio-protective nutrients may make it possible to reduce some of the cognitive and cardiovascular sequelae associated with OSA.

AB - Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlying mechanism(s) for the cognitive deficits and CVD in OSA. A number of studies have suggested that increased levels of oxidative stress and/or antioxidant deficiencies may also be risk factors in cognitive decline and CVD. The influence of antioxidant nutrients and supplements, such as Vitamins B6, B12, C, E, folic acid, alpha-lipoic acid and Coenzyme Q10 on cognitive decline and CVD have been investigated. The influence of antioxidant nutrients or supplements on OSA remains to be investigated. Even if dietary or supplemental antioxidants do not prove to be effective therapies for OSA, dietary assessment and prescription to increase dietary intake of neuro- and cardio-protective nutrients may make it possible to reduce some of the cognitive and cardiovascular sequelae associated with OSA.

KW - Alpha-lipoic acid

KW - Antioxidants

KW - Cardiovascular disease

KW - Coenzyme Q

KW - Cognitive deficits

KW - Cytokines

KW - Homocysteine

KW - Nutrient intake

KW - Obstructive sleep apnea

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=27744558948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744558948&partnerID=8YFLogxK

U2 - 10.1016/j.smrv.2005.04.004

DO - 10.1016/j.smrv.2005.04.004

M3 - Article

VL - 9

SP - 459

EP - 476

JO - Sleep Medicine Reviews

JF - Sleep Medicine Reviews

SN - 1087-0792

IS - 6

ER -