Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea

Carol M. Baldwin, Richard R. Bootzin, Dawn C. Schwenke, Stuart F. Quan

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlying mechanism(s) for the cognitive deficits and CVD in OSA. A number of studies have suggested that increased levels of oxidative stress and/or antioxidant deficiencies may also be risk factors in cognitive decline and CVD. The influence of antioxidant nutrients and supplements, such as Vitamins B6, B12, C, E, folic acid, alpha-lipoic acid and Coenzyme Q10 on cognitive decline and CVD have been investigated. The influence of antioxidant nutrients or supplements on OSA remains to be investigated. Even if dietary or supplemental antioxidants do not prove to be effective therapies for OSA, dietary assessment and prescription to increase dietary intake of neuro- and cardio-protective nutrients may make it possible to reduce some of the cognitive and cardiovascular sequelae associated with OSA.

Original languageEnglish (US)
Pages (from-to)459-476
Number of pages18
JournalSleep Medicine Reviews
Volume9
Issue number6
DOIs
StatePublished - Dec 2005

Keywords

  • Alpha-lipoic acid
  • Antioxidants
  • Cardiovascular disease
  • Coenzyme Q
  • Cognitive deficits
  • Cytokines
  • Homocysteine
  • Nutrient intake
  • Obstructive sleep apnea
  • Oxidative stress

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea'. Together they form a unique fingerprint.

  • Cite this