Antineoplastic and cytotoxic components of desert Baileya

George Pettit, C. L. Herald, G. F. Judd, G. Bolliger, P. S. Thayer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The authors wish to report the isolation of six cytotoxic and antineoplastic constituents of B. multiradiata and that the P 388 in vitro screening technique proved very efficient for this purpose. The results of this bioassay are expressed as ED 50, namely, that concentration of material (in micrograms per milliliter) that produces 50% inhibition of growth in a 48 hr incubation period. Results of the present study suggest that the pseudoguaianolide lactone of the fastigilin, helenalin, and radiatin type possesses (in addition to the usual cytotoxic properties of such lactones) carrier groups that fall within requirements for in vivo antineoplastic activity. Also, the cytotoxicity displayed by the sesquiterpene lactones of B. multiradiata, while correlated with the antineoplastic activity, may suggest that these components are responsible for sheep poisonings attributed to this plant.

Original languageEnglish (US)
Pages (from-to)2023-2024
Number of pages2
JournalJournal of Pharmaceutical Sciences
Volume64
Issue number12
DOIs
StatePublished - 1975

Fingerprint

Lactones
Antineoplastic Agents
Sesquiterpenes
Bioassay
Cytotoxicity
Biological Assay
Poisoning
Sheep
Screening
Growth

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Antineoplastic and cytotoxic components of desert Baileya. / Pettit, George; Herald, C. L.; Judd, G. F.; Bolliger, G.; Thayer, P. S.

In: Journal of Pharmaceutical Sciences, Vol. 64, No. 12, 1975, p. 2023-2024.

Research output: Contribution to journalArticle

Pettit, G, Herald, CL, Judd, GF, Bolliger, G & Thayer, PS 1975, 'Antineoplastic and cytotoxic components of desert Baileya', Journal of Pharmaceutical Sciences, vol. 64, no. 12, pp. 2023-2024. https://doi.org/10.1002/jps.2600641232
Pettit, George ; Herald, C. L. ; Judd, G. F. ; Bolliger, G. ; Thayer, P. S. / Antineoplastic and cytotoxic components of desert Baileya. In: Journal of Pharmaceutical Sciences. 1975 ; Vol. 64, No. 12. pp. 2023-2024.
@article{e6f3d31a356d4899b7b37c9178c36a79,
title = "Antineoplastic and cytotoxic components of desert Baileya",
abstract = "The authors wish to report the isolation of six cytotoxic and antineoplastic constituents of B. multiradiata and that the P 388 in vitro screening technique proved very efficient for this purpose. The results of this bioassay are expressed as ED 50, namely, that concentration of material (in micrograms per milliliter) that produces 50{\%} inhibition of growth in a 48 hr incubation period. Results of the present study suggest that the pseudoguaianolide lactone of the fastigilin, helenalin, and radiatin type possesses (in addition to the usual cytotoxic properties of such lactones) carrier groups that fall within requirements for in vivo antineoplastic activity. Also, the cytotoxicity displayed by the sesquiterpene lactones of B. multiradiata, while correlated with the antineoplastic activity, may suggest that these components are responsible for sheep poisonings attributed to this plant.",
author = "George Pettit and Herald, {C. L.} and Judd, {G. F.} and G. Bolliger and Thayer, {P. S.}",
year = "1975",
doi = "10.1002/jps.2600641232",
language = "English (US)",
volume = "64",
pages = "2023--2024",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

TY - JOUR

T1 - Antineoplastic and cytotoxic components of desert Baileya

AU - Pettit, George

AU - Herald, C. L.

AU - Judd, G. F.

AU - Bolliger, G.

AU - Thayer, P. S.

PY - 1975

Y1 - 1975

N2 - The authors wish to report the isolation of six cytotoxic and antineoplastic constituents of B. multiradiata and that the P 388 in vitro screening technique proved very efficient for this purpose. The results of this bioassay are expressed as ED 50, namely, that concentration of material (in micrograms per milliliter) that produces 50% inhibition of growth in a 48 hr incubation period. Results of the present study suggest that the pseudoguaianolide lactone of the fastigilin, helenalin, and radiatin type possesses (in addition to the usual cytotoxic properties of such lactones) carrier groups that fall within requirements for in vivo antineoplastic activity. Also, the cytotoxicity displayed by the sesquiterpene lactones of B. multiradiata, while correlated with the antineoplastic activity, may suggest that these components are responsible for sheep poisonings attributed to this plant.

AB - The authors wish to report the isolation of six cytotoxic and antineoplastic constituents of B. multiradiata and that the P 388 in vitro screening technique proved very efficient for this purpose. The results of this bioassay are expressed as ED 50, namely, that concentration of material (in micrograms per milliliter) that produces 50% inhibition of growth in a 48 hr incubation period. Results of the present study suggest that the pseudoguaianolide lactone of the fastigilin, helenalin, and radiatin type possesses (in addition to the usual cytotoxic properties of such lactones) carrier groups that fall within requirements for in vivo antineoplastic activity. Also, the cytotoxicity displayed by the sesquiterpene lactones of B. multiradiata, while correlated with the antineoplastic activity, may suggest that these components are responsible for sheep poisonings attributed to this plant.

UR - http://www.scopus.com/inward/record.url?scp=0016719530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016719530&partnerID=8YFLogxK

U2 - 10.1002/jps.2600641232

DO - 10.1002/jps.2600641232

M3 - Article

C2 - 1239501

AN - SCOPUS:0016719530

VL - 64

SP - 2023

EP - 2024

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 12

ER -