Antineoplastic Agents. V. The Aromatic System of Podoph yllotoxin (Part B)

George R. Pettit, Michael F. Baumann, K. N. Rangammal

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Several N-bis(2-chloroethyl)amides have been reduced to their corresponding nitrogen mustard derivatives employing a lithium aluminum hydride-aluminum chloride reagent. The utility of this new approach to nitrogen mustards was illustrated by synthesis of N-bis(2-chloroethyl)-3,4-methylenedioxybenzylamine (X) hydrochloride, N-bis(2-chloroethyl)-3,4,5-trimethoxybenzylamine (XI) hydrochloride and N-bis(2-chloroethyl)-3-(3,4-methylenedioxyphenyl)-3-(3,4,5-trimethoxyphenyl)propylamine (VII) hydrochloride.

Original languageEnglish (US)
Pages (from-to)800-808
Number of pages9
JournalJournal of medicinal and pharmaceutical chemistry
Volume5
Issue number4
DOIs
StatePublished - Jul 1 1962
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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