Antineoplastic agents, 99. amaryllis belladonna

George Pettit, Venkatswamy Gaddamidi, Animesh Goswami, Gordon M. Cragg

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Amaryllis belladonna bulbs were examined for constiuents inhibitory against the murine P-388 lymphocytic leukemia (PS system). Two in vitro active alkaloids, acetylcaranine (2; 9PS ED500.23 μg/ml) and ambelline (3; 9PS ED501.6 μg/ml), were isolated accompanied by undulatine. However, the non-chi ral anhydrolycorinium chloride (5) was found to be the principal antineoplastic (3 PS, 64-69% life extension at dose levels 10 to 20 mg/kg in vivo, ED501.4 μg/ml in vitro) component. Quaternary chloride 5 has not been located previously among plant or animal biosynthetic products.

Original languageEnglish (US)
Pages (from-to)796-801
Number of pages6
JournalJournal of Natural Products
Volume47
Issue number5
DOIs
StatePublished - Oct 1984

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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