Antineoplastic agents, 88. Pimelea prostrata

George Pettit; J. I Chun Zou; Animesh Goswami; Gordon M. Cragg; Jean M. Schmidt

doi:10.1021/np50028a024

Antineoplastic agents, 88. Pimelea prostrata

George Pettit, J. I Chun Zou, Animesh Goswami, Gordon M. Cragg, Jean M. Schmidt

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Abstract

The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 x 10-3 and 8 x 10-4 μg/ml, respectively) of the PS in vitro cell line. The cyclic orthoester (2) was also found to inhibit growth (T/C 132 at 20 μ,g/kg) of the PS in vivo system. Detailed 1H-nmr (at 400 MHz) and 13C-nmr studies combined with fast atom bombardment mass spectral evidence were employed to confirm the structural assignments.

Original language	English (US)
Pages (from-to)	563-568
Number of pages	6
Journal	Journal of Natural Products
Volume	46
Issue number	4
DOIs	https://doi.org/10.1021/np50028a024
State	Published - Jul 1983

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50028a024

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title = "Antineoplastic agents, 88. Pimelea prostrata",

abstract = "The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 x 10-3 and 8 x 10-4 μg/ml, respectively) of the PS in vitro cell line. The cyclic orthoester (2) was also found to inhibit growth (T/C 132 at 20 μ,g/kg) of the PS in vivo system. Detailed 1H-nmr (at 400 MHz) and 13C-nmr studies combined with fast atom bombardment mass spectral evidence were employed to confirm the structural assignments.",

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year = "1983",

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AU - Pettit, George

AU - Zou, J. I Chun

AU - Goswami, Animesh

AU - Cragg, Gordon M.

AU - Schmidt, Jean M.

PY - 1983/7

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AB - The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 x 10-3 and 8 x 10-4 μg/ml, respectively) of the PS in vitro cell line. The cyclic orthoester (2) was also found to inhibit growth (T/C 132 at 20 μ,g/kg) of the PS in vivo system. Detailed 1H-nmr (at 400 MHz) and 13C-nmr studies combined with fast atom bombardment mass spectral evidence were employed to confirm the structural assignments.

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Antineoplastic agents, 88. Pimelea prostrata

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