Antineoplastic agents, 88. Pimelea prostrata

George Pettit, J. I Chun Zou, Animesh Goswami, Gordon M. Cragg, Jean M. Schmidt

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 x 10-3 and 8 x 10-4 μg/ml, respectively) of the PS in vitro cell line. The cyclic orthoester (2) was also found to inhibit growth (T/C 132 at 20 μ,g/kg) of the PS in vivo system. Detailed 1H-nmr (at 400 MHz) and 13C-nmr studies combined with fast atom bombardment mass spectral evidence were employed to confirm the structural assignments.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalJournal of Natural Products
Volume46
Issue number4
DOIs
StatePublished - Jul 1983

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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