Antineoplastic agents 78. Isolation of palystatins 1–3 from the indian ocean Palythoa liscia

George Pettit, Youichi Fujii, Julia A. Hasler, Jean M. Schmidt, Claude Michel

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The Western Indian Ocean Palythoa liscia Haddon and Duerden has been found to contain three cell growth (PS) inhibitory proteins with molecular weights ranging from 128,000 to >2×107. The lowest mass protein from this colonial Zoanthiniarian, palystatin 1 (PS, ED50 1.3–5.5×10−4 µg/ml) may be a sub-unit of the two high mass cytotoxic (PS, ED50 0.01 µg/ml) proteins palystatins 2 and 3. Isolation of paly-statins 1–3 was guided by bioassay (PS in vitro) through a sequence of gel permeation chromatographic methods utilizing Sephadex LH-20 to Sepharose 4B.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalJournal of Natural Products
Volume45
Issue number3
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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