Antineoplastic agents 78. Isolation of palystatins 1–3 from the indian ocean Palythoa liscia

George Pettit; Youichi Fujii; Julia A. Hasler; Jean M. Schmidt; Claude Michel

doi:10.1021/np50021a005

Antineoplastic agents 78. Isolation of palystatins 1–3 from the indian ocean Palythoa liscia

George Pettit, Youichi Fujii, Julia A. Hasler, Jean M. Schmidt, Claude Michel

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Abstract

The Western Indian Ocean Palythoa liscia Haddon and Duerden has been found to contain three cell growth (PS) inhibitory proteins with molecular weights ranging from 128,000 to >2×10⁷. The lowest mass protein from this colonial Zoanthiniarian, palystatin 1 (PS, ED₅₀ 1.3–5.5×10⁻⁴ µg/ml) may be a sub-unit of the two high mass cytotoxic (PS, ED₅₀ 0.01 µg/ml) proteins palystatins 2 and 3. Isolation of paly-statins 1–3 was guided by bioassay (PS in vitro) through a sequence of gel permeation chromatographic methods utilizing Sephadex LH-20 to Sepharose 4B.

Original language	English (US)
Pages (from-to)	263-269
Number of pages	7
Journal	Journal of Natural Products
Volume	45
Issue number	3
DOIs	https://doi.org/10.1021/np50021a005
State	Published - Jan 1 1982

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "The Western Indian Ocean Palythoa liscia Haddon and Duerden has been found to contain three cell growth (PS) inhibitory proteins with molecular weights ranging from 128,000 to >2×107. The lowest mass protein from this colonial Zoanthiniarian, palystatin 1 (PS, ED50 1.3–5.5×10−4 µg/ml) may be a sub-unit of the two high mass cytotoxic (PS, ED50 0.01 µg/ml) proteins palystatins 2 and 3. Isolation of paly-statins 1–3 was guided by bioassay (PS in vitro) through a sequence of gel permeation chromatographic methods utilizing Sephadex LH-20 to Sepharose 4B.",

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AU - Pettit, George

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AU - Hasler, Julia A.

AU - Schmidt, Jean M.

AU - Michel, Claude

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N2 - The Western Indian Ocean Palythoa liscia Haddon and Duerden has been found to contain three cell growth (PS) inhibitory proteins with molecular weights ranging from 128,000 to >2×107. The lowest mass protein from this colonial Zoanthiniarian, palystatin 1 (PS, ED50 1.3–5.5×10−4 µg/ml) may be a sub-unit of the two high mass cytotoxic (PS, ED50 0.01 µg/ml) proteins palystatins 2 and 3. Isolation of paly-statins 1–3 was guided by bioassay (PS in vitro) through a sequence of gel permeation chromatographic methods utilizing Sephadex LH-20 to Sepharose 4B.

AB - The Western Indian Ocean Palythoa liscia Haddon and Duerden has been found to contain three cell growth (PS) inhibitory proteins with molecular weights ranging from 128,000 to >2×107. The lowest mass protein from this colonial Zoanthiniarian, palystatin 1 (PS, ED50 1.3–5.5×10−4 µg/ml) may be a sub-unit of the two high mass cytotoxic (PS, ED50 0.01 µg/ml) proteins palystatins 2 and 3. Isolation of paly-statins 1–3 was guided by bioassay (PS in vitro) through a sequence of gel permeation chromatographic methods utilizing Sephadex LH-20 to Sepharose 4B.

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Antineoplastic agents 78. Isolation of palystatins 1–3 from the indian ocean Palythoa liscia

Abstract

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