Antineoplastic agents 78. Isolation of palystatins 1-3 from the Indian Ocean Palythoa liscia

George Pettit, Youichi Fujii, Julia A. Hasler, Jean M. Schmidt, Claude Michel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The Western Indian Ocean Palythoa liscia Haddon and Duerden has been found to contain three cell growth (PS) inhibitory proteins with molecular weights ranging from 128,000 to > 2x107. The lowest mass protein from this colonial Zoanthiniarian, palystatin 1 (PS, ED50 1.3-5.5x10-4 μg/ml) may be a sub-unit of the two high mass cytotoxic (PS, ED50 0.01 μg/ml) proteins palystatins 2 and 3. Isolation of palystatins 1-3 was guided by bioassay (PS in vitro) through a sequence of gel permeation chromatographic methods utilizing Sephadex LH-20 to Sepharose 4B.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalJournal of Natural Products
Volume45
Issue number3
StatePublished - 1982

Fingerprint

Indian Ocean
antineoplastic agents
Antineoplastic Agents
Biological Assay
Sepharose
Proteins
proteins
Bioassay
Molecular Weight
Gels
Cell growth
Permeation
agarose
cell growth
bioassays
Molecular weight
gels
molecular weight
methodology
In Vitro Techniques

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic agents 78. Isolation of palystatins 1-3 from the Indian Ocean Palythoa liscia. / Pettit, George; Fujii, Youichi; Hasler, Julia A.; Schmidt, Jean M.; Michel, Claude.

In: Journal of Natural Products, Vol. 45, No. 3, 1982, p. 263-269.

Research output: Contribution to journalArticle

Pettit, G, Fujii, Y, Hasler, JA, Schmidt, JM & Michel, C 1982, 'Antineoplastic agents 78. Isolation of palystatins 1-3 from the Indian Ocean Palythoa liscia', Journal of Natural Products, vol. 45, no. 3, pp. 263-269.
Pettit, George ; Fujii, Youichi ; Hasler, Julia A. ; Schmidt, Jean M. ; Michel, Claude. / Antineoplastic agents 78. Isolation of palystatins 1-3 from the Indian Ocean Palythoa liscia. In: Journal of Natural Products. 1982 ; Vol. 45, No. 3. pp. 263-269.
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