Antineoplastic agents. 76. the sea urchin strongylocentrotus droeba chiensis

George Pettit, Julia A. Hasler, Kenneth D. Paull, Cherry L. Herald

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P3S8 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.

Original languageEnglish (US)
Pages (from-to)701-704
Number of pages4
JournalJournal of Natural Products
Volume44
Issue number6
DOIs
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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