Antineoplastic agents. 76. the sea urchin strongylocentrotus droeba chiensis

George Pettit; Julia A. Hasler; Kenneth D. Paull; Cherry L. Herald

doi:10.1021/np50018a015

Antineoplastic agents. 76. the sea urchin strongylocentrotus droeba chiensis

George Pettit, Julia A. Hasler, Kenneth D. Paull, Cherry L. Herald

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P3S8 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.

Original language	English (US)
Pages (from-to)	701-704
Number of pages	4
Journal	Journal of Natural Products
Volume	44
Issue number	6
DOIs	https://doi.org/10.1021/np50018a015
State	Published - Nov 1981

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50018a015

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abstract = "An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (M{\"u}ller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P3S8 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.",

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AU - Paull, Kenneth D.

AU - Herald, Cherry L.

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Y1 - 1981/11

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AB - An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P3S8 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.

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Antineoplastic agents. 76. the sea urchin strongylocentrotus droeba chiensis

Abstract

ASJC Scopus subject areas

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