Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism

George Pettit, Rui Tan, Robin Pettit, Dennis L. Doubek, Jean Chapuis, Christine A. Weber

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A microorganism identified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (2) designated chromomycin A5 (5). Chromomycin A5 displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI50 0.00073 μg mL-1) against a mini-panel of murine and human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)9116-9122
Number of pages7
JournalRSC Advances
Volume5
Issue number12
DOIs
StatePublished - 2015

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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