Abstract
Three advances necessary to bring dolastatin 16 (1) into full-scale preclinical development as an anticancer drug have been accomplished. The X-ray crystal structure of dolastatin 16 has been solved, which allowed stereoselective syntheses of its two new amino acid units, dolamethylleuine (Dml) and dolaphenvaline (Dpv), to be completed. The X-ray crystal structures of synthetic Z-Dml and TFA-Dpv have also been completed. (Chemical Equation Presented).
Original language | English (US) |
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Pages (from-to) | 1003-1008 |
Number of pages | 6 |
Journal | Journal of Natural Products |
Volume | 74 |
Issue number | 5 |
DOIs | |
State | Published - May 27 2011 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry