Antineoplastic agents. 575. The fungus Aspergillus phoenicis

George Pettit, Jiang Du, Robin Pettit, John C. Knight, Dennis L. Doubek

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Cancer cell line bioassay-guided separation of an extract from the fungus Aspergillus phoenicis collected in Saskatchewan, Canada, resulted in the isolation of three new constituents designated asperlactone (1), aspergillol A (2), and aspergillol B (3), accompanied by four previously known constituents: asperic acid (4), hexylitaconic acid (5), methyl 2-hydroxyphenylacetate (6), and methyl 4-hydroxyphenylacetate (7). The structure of each was determined by analyses of high-resolution mass spectra and high-field NMR data. Asperic acid (4) was found to inhibit growth of the murine lymphocytic leukemia P388 (ED50 0.18 Hg/mL) and a panel of human cancer cell lines (GI50 1.7-2.0 μg/mL; pancreas, breast, CNS, lung, colon, and prostate), while aspergillol A (2) showed moderate inhibition against the breast adenocarcinoma MCF-7 (GI50 7.2 μg/mL).

Original languageEnglish (US)
Pages (from-to)909-916
Number of pages8
JournalHeterocycles
Volume79
Issue numberC
DOIs
StatePublished - Jul 29 2009

Keywords

  • Aromatic Alcohol
  • Cancer Cell Inhibition
  • Fungal Metabolite
  • Lactone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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