Antineoplastic agents. 573. Isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa

George Pettit, Qinghua Ye, Delbert L. Herald, Fiona Hogan, Robin Pettit

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (la). The structure was determined by analysis of ID and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI50's of 0.093-3.5 μg/mL. Papilistatin was also found to have antibacterial activity.

Original languageEnglish (US)
Pages (from-to)164-166
Number of pages3
JournalJournal of Natural Products
Volume73
Issue number2
DOIs
StatePublished - Feb 26 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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