Antineoplastic agents. 573. Isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa

George Pettit; Qinghua Ye; Delbert L. Herald; Fiona Hogan; Robin Pettit

doi:10.1021/np9004689

Antineoplastic agents. 573. Isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa

George Pettit, Qinghua Ye, Delbert L. Herald, Fiona Hogan, Robin Pettit

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (la). The structure was determined by analysis of ID and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI₅₀'s of 0.093-3.5 μg/mL. Papilistatin was also found to have antibacterial activity.

Original language	English (US)
Pages (from-to)	164-166
Number of pages	3
Journal	Journal of Natural Products
Volume	73
Issue number	2
DOIs	https://doi.org/10.1021/np9004689
State	Published - Feb 26 2010

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np9004689

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abstract = "Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (la). The structure was determined by analysis of ID and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI50's of 0.093-3.5 μg/mL. Papilistatin was also found to have antibacterial activity.",

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AU - Hogan, Fiona

AU - Pettit, Robin

PY - 2010/2/26

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AB - Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (la). The structure was determined by analysis of ID and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI50's of 0.093-3.5 μg/mL. Papilistatin was also found to have antibacterial activity.

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Antineoplastic agents. 573. Isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa

Abstract

ASJC Scopus subject areas

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