Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George Pettit, John C. Knight, Delbert L. Herald, Robin Pettit, Fiona Hogan, Venugopal J R V Mukku, John S. Hamblin, Michael J. Dodson, Jean Chapuis

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalJournal of Natural Products
Volume72
Issue number3
DOIs
StatePublished - Mar 27 2009

Fingerprint

Depsipeptides
Bacilli
Antineoplastic Agents
Bacillus
Pacific Ocean
Chile
Streptococcus pneumoniae
X-Ray Diffraction
Cells
Nuclear magnetic resonance
Anti-Bacterial Agents
Cell Line
X ray diffraction
Degradation
Growth
Neoplasms
bacillistatin 1
bacillistatin 2

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris. / Pettit, George; Knight, John C.; Herald, Delbert L.; Pettit, Robin; Hogan, Fiona; Mukku, Venugopal J R V; Hamblin, John S.; Dodson, Michael J.; Chapuis, Jean.

In: Journal of Natural Products, Vol. 72, No. 3, 27.03.2009, p. 366-371.

Research output: Contribution to journalArticle

Pettit, George ; Knight, John C. ; Herald, Delbert L. ; Pettit, Robin ; Hogan, Fiona ; Mukku, Venugopal J R V ; Hamblin, John S. ; Dodson, Michael J. ; Chapuis, Jean. / Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris. In: Journal of Natural Products. 2009 ; Vol. 72, No. 3. pp. 366-371.
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