Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George Pettit, John C. Knight, Delbert L. Herald, Robin Pettit, Fiona Hogan, Venugopal J R V Mukku, John S. Hamblin, Michael J. Dodson, Jean Chapuis

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalJournal of Natural Products
Volume72
Issue number3
DOIs
StatePublished - Mar 27 2009

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Pettit, G., Knight, J. C., Herald, D. L., Pettit, R., Hogan, F., Mukku, V. J. R. V., Hamblin, J. S., Dodson, M. J., & Chapuis, J. (2009). Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris. Journal of Natural Products, 72(3), 366-371. https://doi.org/10.1021/np800603u