Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Pettit, G. R. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Pettit, R. K. (Creator), Hogan, F. (Creator), Mukku, V. J. R. V. (Creator), Hamblin, J. S. (Creator), Dodson II, M. J. (Contributor) & Chapuis, J. (Creator), The Cambridge Structural Database, 2010