Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

George Pettit, Venugopal J R V Mukku, Gordon Cragg, Delbert L. Herald, John C. Knight, Cherry L. Herald, Jean Chapuis

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number1
DOIs
StatePublished - Jan 1 2008

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Pettit, G., Mukku, V. J. R. V., Cragg, G., Herald, D. L., Knight, J. C., Herald, C. L., & Chapuis, J. (2008). Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents. Journal of Natural Products, 71(1), 130-133. https://doi.org/10.1021/np068050q