An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
FingerprintDive into the research topics of 'Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents'. Together they form a unique fingerprint.
Pettit, G. R. (Contributor), Herald, C. L. (Contributor), Mukku, V. J. R. V. (Contributor), Herald, D. L. (Contributor), Chapuis, J. (Contributor), Knight, J. C. (Contributor) & Cragg, G. (Contributor), The Cambridge Structural Database, Jan 1 2008