Antineoplastic agents. 554. The Manitoba bacterium Streptomyces sp.

George Pettit, Jiang Du, Robin Pettit, Linda A. Richert, Fiona Hogan, Venugopal J R V Mukku, Michael S. Hoard

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 μg/mL) growth of a minipanel of human cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit cancer cell growth.

Original languageEnglish (US)
Pages (from-to)804-806
Number of pages3
JournalJournal of Natural Products
Volume69
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Manitoba
antineoplastic agents
Streptomyces
Cell growth
Antineoplastic Agents
Bacteria
indoles
cell growth
bacteria
Growth
riparian soils
Neisseria gonorrhoeae
lymphocytic leukemia
Streptococcus pneumoniae
human growth
Cells
Nuclear magnetic resonance
Lymphoid Leukemia
Soils
Neoplasms

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic agents. 554. The Manitoba bacterium Streptomyces sp. / Pettit, George; Du, Jiang; Pettit, Robin; Richert, Linda A.; Hogan, Fiona; Mukku, Venugopal J R V; Hoard, Michael S.

In: Journal of Natural Products, Vol. 69, No. 5, 05.2006, p. 804-806.

Research output: Contribution to journalArticle

Pettit, George ; Du, Jiang ; Pettit, Robin ; Richert, Linda A. ; Hogan, Fiona ; Mukku, Venugopal J R V ; Hoard, Michael S. / Antineoplastic agents. 554. The Manitoba bacterium Streptomyces sp. In: Journal of Natural Products. 2006 ; Vol. 69, No. 5. pp. 804-806.
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