Antineoplastic agents. 554. The Manitoba bacterium Streptomyces sp.

George Pettit, Jiang Du, Robin Pettit, Linda A. Richert, Fiona Hogan, Venugopal J R V Mukku, Michael S. Hoard

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 μg/mL) growth of a minipanel of human cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit cancer cell growth.

Original languageEnglish (US)
Pages (from-to)804-806
Number of pages3
JournalJournal of Natural Products
Volume69
Issue number5
DOIs
StatePublished - May 1 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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