Antineoplastic agents. 551. Isolation and structures of Bauhiniastatins 1-4 from Bauhinia purpurea

George Pettit, Atsushi Numata, Chika Iwamoto, Yoshihide Usami, Takeshi Yamada, Hirofumi Ohishi, Gordon M. Cragg

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of human cancer cell lines, and bauhiniastatin 1 (2a) was also found to inhibit the P388 cancer cell line. Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalJournal of Natural Products
Volume69
Issue number3
DOIs
StatePublished - Mar 2006

Fingerprint

Bauhinia purpurea
Bauhinia
antineoplastic agents
Antineoplastic Agents
Growth Inhibitors
Cells
cell lines
Oxepins
Cell Line
cell growth
Neoplasms
Bioassay
Lymphoid Leukemia
lymphocytic leukemia
Cell Separation
Nuclear magnetic resonance
Biological Assay
growth retardation
Derivatives
pods

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic agents. 551. Isolation and structures of Bauhiniastatins 1-4 from Bauhinia purpurea. / Pettit, George; Numata, Atsushi; Iwamoto, Chika; Usami, Yoshihide; Yamada, Takeshi; Ohishi, Hirofumi; Cragg, Gordon M.

In: Journal of Natural Products, Vol. 69, No. 3, 03.2006, p. 323-327.

Research output: Contribution to journalArticle

Pettit, George ; Numata, Atsushi ; Iwamoto, Chika ; Usami, Yoshihide ; Yamada, Takeshi ; Ohishi, Hirofumi ; Cragg, Gordon M. / Antineoplastic agents. 551. Isolation and structures of Bauhiniastatins 1-4 from Bauhinia purpurea. In: Journal of Natural Products. 2006 ; Vol. 69, No. 3. pp. 323-327.
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