Antineoplastic agents. 551. Isolation and structures of Bauhiniastatins 1-4 from Bauhinia purpurea

George Pettit, Atsushi Numata, Chika Iwamoto, Yoshihide Usami, Takeshi Yamada, Hirofumi Ohishi, Gordon M. Cragg

Research output: Contribution to journalArticle

71 Scopus citations


Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of human cancer cell lines, and bauhiniastatin 1 (2a) was also found to inhibit the P388 cancer cell line. Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalJournal of Natural Products
Issue number3
StatePublished - Mar 1 2006


ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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