Abstract
Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of human cancer cell lines, and bauhiniastatin 1 (2a) was also found to inhibit the P388 cancer cell line. Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 323-327 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 69 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2006 |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Antineoplastic agents. 551. Isolation and structures of Bauhiniastatins 1-4 from Bauhinia purpurea. / Pettit, George; Numata, Atsushi; Iwamoto, Chika; Usami, Yoshihide; Yamada, Takeshi; Ohishi, Hirofumi; Cragg, Gordon M.
In: Journal of Natural Products, Vol. 69, No. 3, 03.2006, p. 323-327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antineoplastic agents. 551. Isolation and structures of Bauhiniastatins 1-4 from Bauhinia purpurea
AU - Pettit, George
AU - Numata, Atsushi
AU - Iwamoto, Chika
AU - Usami, Yoshihide
AU - Yamada, Takeshi
AU - Ohishi, Hirofumi
AU - Cragg, Gordon M.
PY - 2006/3
Y1 - 2006/3
N2 - Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of human cancer cell lines, and bauhiniastatin 1 (2a) was also found to inhibit the P388 cancer cell line. Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR.
AB - Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of human cancer cell lines, and bauhiniastatin 1 (2a) was also found to inhibit the P388 cancer cell line. Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR.
UR - http://www.scopus.com/inward/record.url?scp=33646012281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646012281&partnerID=8YFLogxK
U2 - 10.1021/np058075+
DO - 10.1021/np058075+
M3 - Article
C2 - 16562827
AN - SCOPUS:33646012281
VL - 69
SP - 323
EP - 327
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 3
ER -