Abstract
Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (lc) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (lc), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (lb), fastigilin C (2a), and multiradiatin (2c).
Original language | English (US) |
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Pages (from-to) | 1092-1095 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 43 |
Issue number | 6 |
DOIs | |
State | Published - 1978 |
ASJC Scopus subject areas
- Organic Chemistry