Antineoplastic Agents. 55. Isolation and Structure of Multigilin and Multistatin

George Pettit, Cherry L. Herald, Devens Gust, Delbert L. Herald, Lawrence D. Vanell

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (lc) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (lc), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (lb), fastigilin C (2a), and multiradiatin (2c).

Original languageEnglish (US)
Pages (from-to)1092-1095
Number of pages4
JournalJournal of Organic Chemistry
Volume43
Issue number6
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Organic Chemistry

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