Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (lc) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (lc), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (lb), fastigilin C (2a), and multiradiatin (2c).
ASJC Scopus subject areas
- Organic Chemistry