Antineoplastic agents. 545. Isolation and structure of turbostatins 1-4 from the Asian marine mollusk Turbo stenogyrus

George Pettit, Yuping Tang, John C. Knight

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The cancer cell line bioassay-guided separation of an extract from the marine mollusk Turbo stenogyrus led to the isolation of four new cerebrosides designated turbostatins 1-4 (1-4). The structure of each glycolipid was determined by interpreting results of a series of HR-APCI-MS and NMR (1D and 2D) spectral analyses. All four turbostatins exhibited significant (GI50 0.15-2.6 μg/mL) cancer cell growth inhibition against the murine P388 lymphocytic leukemia and a panel of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)974-978
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number7
DOIs
StatePublished - Jul 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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