Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae)

George Pettit, Yanhui Meng, Delbert L. Herald, Andrew M. Stevens, Robin Pettit, Dennis L. Doubek

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The CH3OH-CH2Cl2 extract of an Indian collection (entire plant) of Gynandropsis gynandra (L.) Briq. was separated based on bioassay results employing cancer cell lines. Six cancer cell growth inhibitors were isolated and found to be known flavone apegenin (4) and flavonols 1-3, 5, and 6. The structure of flavonol 2 was confirmed by X-ray crystal structure determination. All of the five flavonols (1-3, 5, 6) inhibited the murine P388 lymphocytic leukemia cell line with ED50 values of 3.0, 9.2, 4.0, 0.37, and 3.9 μg/ml, respectively. All six of the flavonoids (1-6) also exhibited activity against a panel of six human cancer cell lines. Penduletin (3) inhibited growth of the Gram-negative pathogen Neisseria gonorrhoeae and apegenin (4) inhibited growth of the Gram-positive opportunist Enterococcus faecalis.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalOncology Research
Volume15
Issue number2
StatePublished - 2005

Fingerprint

Antineoplastic Agents
Flavonols
flavone
Cell Line
Lymphoid Leukemia
Neoplasms
Growth Inhibitors
Neisseria gonorrhoeae
Enterococcus faecalis
Growth
Flavonoids
Biological Assay
X-Rays
penduletin
3-hydroxyflavone

Keywords

  • Anticancer activities
  • Antimicrobial activities
  • Capparidaceae
  • Flavones
  • Gynandropsis gynandra

ASJC Scopus subject areas

  • Cancer Research

Cite this

Pettit, G., Meng, Y., Herald, D. L., Stevens, A. M., Pettit, R., & Doubek, D. L. (2005). Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae). Oncology Research, 15(2), 59-68.

Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae). / Pettit, George; Meng, Yanhui; Herald, Delbert L.; Stevens, Andrew M.; Pettit, Robin; Doubek, Dennis L.

In: Oncology Research, Vol. 15, No. 2, 2005, p. 59-68.

Research output: Contribution to journalArticle

Pettit, G, Meng, Y, Herald, DL, Stevens, AM, Pettit, R & Doubek, DL 2005, 'Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae)', Oncology Research, vol. 15, no. 2, pp. 59-68.
Pettit, George ; Meng, Yanhui ; Herald, Delbert L. ; Stevens, Andrew M. ; Pettit, Robin ; Doubek, Dennis L. / Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae). In: Oncology Research. 2005 ; Vol. 15, No. 2. pp. 59-68.
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