Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae)

George Pettit; Yanhui Meng; Delbert L. Herald; Andrew M. Stevens; Robin Pettit; Dennis L. Doubek

doi:10.3727/096504005775082039

Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae)

George Pettit, Yanhui Meng, Delbert L. Herald, Andrew M. Stevens, Robin Pettit, Dennis L. Doubek

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The CH₃OH-CH₂Cl₂ extract of an Indian collection (entire plant) of Gynandropsis gynandra (L.) Briq. was separated based on bioassay results employing cancer cell lines. Six cancer cell growth inhibitors were isolated and found to be known flavone apegenin (4) and flavonols 1-3, 5, and 6. The structure of flavonol 2 was confirmed by X-ray crystal structure determination. All of the five flavonols (1-3, 5, 6) inhibited the murine P388 lymphocytic leukemia cell line with ED₅₀ values of 3.0, 9.2, 4.0, 0.37, and 3.9 μg/ml, respectively. All six of the flavonoids (1-6) also exhibited activity against a panel of six human cancer cell lines. Penduletin (3) inhibited growth of the Gram-negative pathogen Neisseria gonorrhoeae and apegenin (4) inhibited growth of the Gram-positive opportunist Enterococcus faecalis.

Original language	English (US)
Pages (from-to)	59-68
Number of pages	10
Journal	Oncology Research
Volume	15
Issue number	2
DOIs	https://doi.org/10.3727/096504005775082039
State	Published - 2005

Keywords

Anticancer activities
Antimicrobial activities
Capparidaceae
Flavones
Gynandropsis gynandra

ASJC Scopus subject areas

Medicine(all)

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10.3727/096504005775082039

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title = "Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae)",

abstract = "The CH3OH-CH2Cl2 extract of an Indian collection (entire plant) of Gynandropsis gynandra (L.) Briq. was separated based on bioassay results employing cancer cell lines. Six cancer cell growth inhibitors were isolated and found to be known flavone apegenin (4) and flavonols 1-3, 5, and 6. The structure of flavonol 2 was confirmed by X-ray crystal structure determination. All of the five flavonols (1-3, 5, 6) inhibited the murine P388 lymphocytic leukemia cell line with ED50 values of 3.0, 9.2, 4.0, 0.37, and 3.9 μg/ml, respectively. All six of the flavonoids (1-6) also exhibited activity against a panel of six human cancer cell lines. Penduletin (3) inhibited growth of the Gram-negative pathogen Neisseria gonorrhoeae and apegenin (4) inhibited growth of the Gram-positive opportunist Enterococcus faecalis.",

keywords = "Anticancer activities, Antimicrobial activities, Capparidaceae, Flavones, Gynandropsis gynandra",

author = "George Pettit and Yanhui Meng and Herald, {Delbert L.} and Stevens, {Andrew M.} and Robin Pettit and Doubek, {Dennis L.}",

year = "2005",

doi = "10.3727/096504005775082039",

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AU - Pettit, George

AU - Meng, Yanhui

AU - Herald, Delbert L.

AU - Stevens, Andrew M.

AU - Pettit, Robin

AU - Doubek, Dennis L.

PY - 2005

Y1 - 2005

N2 - The CH3OH-CH2Cl2 extract of an Indian collection (entire plant) of Gynandropsis gynandra (L.) Briq. was separated based on bioassay results employing cancer cell lines. Six cancer cell growth inhibitors were isolated and found to be known flavone apegenin (4) and flavonols 1-3, 5, and 6. The structure of flavonol 2 was confirmed by X-ray crystal structure determination. All of the five flavonols (1-3, 5, 6) inhibited the murine P388 lymphocytic leukemia cell line with ED50 values of 3.0, 9.2, 4.0, 0.37, and 3.9 μg/ml, respectively. All six of the flavonoids (1-6) also exhibited activity against a panel of six human cancer cell lines. Penduletin (3) inhibited growth of the Gram-negative pathogen Neisseria gonorrhoeae and apegenin (4) inhibited growth of the Gram-positive opportunist Enterococcus faecalis.

AB - The CH3OH-CH2Cl2 extract of an Indian collection (entire plant) of Gynandropsis gynandra (L.) Briq. was separated based on bioassay results employing cancer cell lines. Six cancer cell growth inhibitors were isolated and found to be known flavone apegenin (4) and flavonols 1-3, 5, and 6. The structure of flavonol 2 was confirmed by X-ray crystal structure determination. All of the five flavonols (1-3, 5, 6) inhibited the murine P388 lymphocytic leukemia cell line with ED50 values of 3.0, 9.2, 4.0, 0.37, and 3.9 μg/ml, respectively. All six of the flavonoids (1-6) also exhibited activity against a panel of six human cancer cell lines. Penduletin (3) inhibited growth of the Gram-negative pathogen Neisseria gonorrhoeae and apegenin (4) inhibited growth of the Gram-positive opportunist Enterococcus faecalis.

KW - Anticancer activities

KW - Antimicrobial activities

KW - Capparidaceae

KW - Flavones

KW - Gynandropsis gynandra

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Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae)

Abstract

Keywords

ASJC Scopus subject areas

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