Antineoplastic Agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms

George Pettit, Fiona Hogan, Jun-Ping Xu, Rui Tan, Toshihiko Nogawa, Zbigniew Cichacz, Robin Pettit, Jiang Du, Qing Hua Ye, Gordon M. Cragg, Cherry L. Herald, Michael S. Hoard, Animesh Goswami, Justin Searcy, Larry Tackett, Dennis L. Doubek, Lee Williams, John N A Hooper, Jean M. Schmidt, Jean ChapuisDenise N. Tackett, Felicia Craciunescu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Bioassay-guided fractionation of extracts of various plants, marine organisms, and microorganisms has led to the discovery of new natural sources of a number of known compounds that have significant biological activity. The isolation of interesting and valuable cancer cell growth inhibitors including majusculamide C (1), axinastatin 5 (5), bengazoles A (6), B (7), and E (8), manzamine A (10), jaspamide (11), and neoechinulin A (19) has been summarized.

Original languageEnglish (US)
Pages (from-to)438-444
Number of pages7
JournalJournal of Natural Products
Volume71
Issue number3
DOIs
StatePublished - Mar 2008

Fingerprint

jasplakinolide
Aquatic Organisms
Growth Inhibitors
Bioassay
antineoplastic agents
Plant Extracts
Fractionation
Bioactivity
plant extracts
Biological Assay
Microorganisms
Antineoplastic Agents
bioactive properties
cell growth
fractionation
bioassays
microorganisms
organisms
Neoplasms
manzamine A

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic Agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms. / Pettit, George; Hogan, Fiona; Xu, Jun-Ping; Tan, Rui; Nogawa, Toshihiko; Cichacz, Zbigniew; Pettit, Robin; Du, Jiang; Ye, Qing Hua; Cragg, Gordon M.; Herald, Cherry L.; Hoard, Michael S.; Goswami, Animesh; Searcy, Justin; Tackett, Larry; Doubek, Dennis L.; Williams, Lee; Hooper, John N A; Schmidt, Jean M.; Chapuis, Jean; Tackett, Denise N.; Craciunescu, Felicia.

In: Journal of Natural Products, Vol. 71, No. 3, 03.2008, p. 438-444.

Research output: Contribution to journalArticle

Pettit, G, Hogan, F, Xu, J-P, Tan, R, Nogawa, T, Cichacz, Z, Pettit, R, Du, J, Ye, QH, Cragg, GM, Herald, CL, Hoard, MS, Goswami, A, Searcy, J, Tackett, L, Doubek, DL, Williams, L, Hooper, JNA, Schmidt, JM, Chapuis, J, Tackett, DN & Craciunescu, F 2008, 'Antineoplastic Agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms', Journal of Natural Products, vol. 71, no. 3, pp. 438-444. https://doi.org/10.1021/np700738k
Pettit, George ; Hogan, Fiona ; Xu, Jun-Ping ; Tan, Rui ; Nogawa, Toshihiko ; Cichacz, Zbigniew ; Pettit, Robin ; Du, Jiang ; Ye, Qing Hua ; Cragg, Gordon M. ; Herald, Cherry L. ; Hoard, Michael S. ; Goswami, Animesh ; Searcy, Justin ; Tackett, Larry ; Doubek, Dennis L. ; Williams, Lee ; Hooper, John N A ; Schmidt, Jean M. ; Chapuis, Jean ; Tackett, Denise N. ; Craciunescu, Felicia. / Antineoplastic Agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms. In: Journal of Natural Products. 2008 ; Vol. 71, No. 3. pp. 438-444.
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