Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra

George Pettit, Toshihiko Nogawa, John C. Knight, Dennis L. Doubek, J. N A Hoopert

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra. The structures of plakorstatins 1 and 2 including relative configuration were elucidated on the basis of mass and 2D NMR spectroscopic interpretations. These are the first plakortides with an epoxy group in the side chain. Plakorstatin 2 was found to differ from plakorstatin 1 only in the configuration of the epoxide group. Both exhibited moderate cancer cell growth inhibition against the murine P388 lymphocytic leukemia cell line with ED50 values of 1.1 and 0.91, μg/mL, respectively, for peroxides 1 and 2.

Original languageEnglish (US)
Pages (from-to)1611-1613
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number9
DOIs
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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