Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra

George Pettit; Toshihiko Nogawa; John C. Knight; Dennis L. Doubek; J. N A Hoopert

doi:10.1021/np040043j

Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra

George Pettit, Toshihiko Nogawa, John C. Knight, Dennis L. Doubek, J. N A Hoopert

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22 Scopus citations

Abstract

Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra. The structures of plakorstatins 1 and 2 including relative configuration were elucidated on the basis of mass and 2D NMR spectroscopic interpretations. These are the first plakortides with an epoxy group in the side chain. Plakorstatin 2 was found to differ from plakorstatin 1 only in the configuration of the epoxide group. Both exhibited moderate cancer cell growth inhibition against the murine P388 lymphocytic leukemia cell line with ED₅₀ values of 1.1 and 0.91, μg/mL, respectively, for peroxides 1 and 2.

Original language	English (US)
Pages (from-to)	1611-1613
Number of pages	3
Journal	Journal of Natural Products
Volume	67
Issue number	9
DOIs	https://doi.org/10.1021/np040043j
State	Published - Sep 2004

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra",

abstract = "Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra. The structures of plakorstatins 1 and 2 including relative configuration were elucidated on the basis of mass and 2D NMR spectroscopic interpretations. These are the first plakortides with an epoxy group in the side chain. Plakorstatin 2 was found to differ from plakorstatin 1 only in the configuration of the epoxide group. Both exhibited moderate cancer cell growth inhibition against the murine P388 lymphocytic leukemia cell line with ED50 values of 1.1 and 0.91, μg/mL, respectively, for peroxides 1 and 2.",

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AU - Nogawa, Toshihiko

AU - Knight, John C.

AU - Doubek, Dennis L.

AU - Hoopert, J. N A

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AB - Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra. The structures of plakorstatins 1 and 2 including relative configuration were elucidated on the basis of mass and 2D NMR spectroscopic interpretations. These are the first plakortides with an epoxy group in the side chain. Plakorstatin 2 was found to differ from plakorstatin 1 only in the configuration of the epoxide group. Both exhibited moderate cancer cell growth inhibition against the murine P388 lymphocytic leukemia cell line with ED50 values of 1.1 and 0.91, μg/mL, respectively, for peroxides 1 and 2.

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Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra

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