Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra

George Pettit, Toshihiko Nogawa, John C. Knight, Dennis L. Doubek, J. N A Hoopert

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra. The structures of plakorstatins 1 and 2 including relative configuration were elucidated on the basis of mass and 2D NMR spectroscopic interpretations. These are the first plakortides with an epoxy group in the side chain. Plakorstatin 2 was found to differ from plakorstatin 1 only in the configuration of the epoxide group. Both exhibited moderate cancer cell growth inhibition against the murine P388 lymphocytic leukemia cell line with ED50 values of 1.1 and 0.91, μg/mL, respectively, for peroxides 1 and 2.

Original languageEnglish (US)
Pages (from-to)1611-1613
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number9
DOIs
StatePublished - Sep 2004

Fingerprint

Plakortis
antineoplastic agents
Porifera
peroxides
epoxides
Antineoplastic Agents
cell growth
Peroxides
Cell growth
lymphocytic leukemia
growth retardation
Lymphoid Leukemia
Epoxy Compounds
cell lines
Growth
Neoplasms
mice
Cells
Nuclear magnetic resonance
Cell Line

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra. / Pettit, George; Nogawa, Toshihiko; Knight, John C.; Doubek, Dennis L.; Hoopert, J. N A.

In: Journal of Natural Products, Vol. 67, No. 9, 09.2004, p. 1611-1613.

Research output: Contribution to journalArticle

Pettit, George ; Nogawa, Toshihiko ; Knight, John C. ; Doubek, Dennis L. ; Hoopert, J. N A. / Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra. In: Journal of Natural Products. 2004 ; Vol. 67, No. 9. pp. 1611-1613.
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