Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii

George Pettit, Qingwen Zhang, Veronique Pinilla, Holger Hoffmann, John C. Knight, Dennis L. Doubek, Jean Chapuis, Robin Pettit, Jean M. Schmidt

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5% yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.

Original languageEnglish (US)
Pages (from-to)729-733
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number5
DOIs
StatePublished - May 1 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii'. Together they form a unique fingerprint.

  • Cite this