Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii

George Pettit; Qingwen Zhang; Veronique Pinilla; Holger Hoffmann; John C. Knight; Dennis L. Doubek; Jean Chapuis; Robin Pettit; Jean M. Schmidt

doi:10.1021/np040203r

Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii

George Pettit, Qingwen Zhang, Veronique Pinilla, Holger Hoffmann, John C. Knight, Dennis L. Doubek, Jean Chapuis, Robin Pettit, Jean M. Schmidt

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10^-5% yield) from the CH₃OH-CH ₂Cl₂ extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.

Original language	English (US)
Pages (from-to)	729-733
Number of pages	5
Journal	Journal of Natural Products
Volume	68
Issue number	5
DOIs	https://doi.org/10.1021/np040203r
State	Published - May 2005

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np040203r

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title = "Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii",

abstract = "Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5% yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.",

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AU - Pettit, George

AU - Zhang, Qingwen

AU - Pinilla, Veronique

AU - Hoffmann, Holger

AU - Knight, John C.

AU - Doubek, Dennis L.

AU - Chapuis, Jean

AU - Pettit, Robin

AU - Schmidt, Jean M.

PY - 2005/5

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N2 - Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5% yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.

AB - Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5% yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.

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Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii

Abstract

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