Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii

George Pettit, Qingwen Zhang, Veronique Pinilla, Holger Hoffmann, John C. Knight, Dennis L. Doubek, Jean Chapuis, Robin Pettit, Jean M. Schmidt

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5% yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.

Original languageEnglish (US)
Pages (from-to)729-733
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Sansevieria
antineoplastic agents
Saponins
saponins
Antineoplastic Agents
cell lines
steroid saponins
lymphocytic leukemia
Spirostans
Cryptococcus neoformans
Cells
Lymphoid Leukemia
Candida albicans
Cell Line
Spectroscopic analysis
Candida
cell growth
Cell growth
anti-infective agents
Bioactivity

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii. / Pettit, George; Zhang, Qingwen; Pinilla, Veronique; Hoffmann, Holger; Knight, John C.; Doubek, Dennis L.; Chapuis, Jean; Pettit, Robin; Schmidt, Jean M.

In: Journal of Natural Products, Vol. 68, No. 5, 05.2005, p. 729-733.

Research output: Contribution to journalArticle

Pettit, George ; Zhang, Qingwen ; Pinilla, Veronique ; Hoffmann, Holger ; Knight, John C. ; Doubek, Dennis L. ; Chapuis, Jean ; Pettit, Robin ; Schmidt, Jean M. / Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii. In: Journal of Natural Products. 2005 ; Vol. 68, No. 5. pp. 729-733.
@article{35a1293d7945417186bbba3e7c4bfc54,
title = "Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii",
abstract = "Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5{\%} yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.",
author = "George Pettit and Qingwen Zhang and Veronique Pinilla and Holger Hoffmann and Knight, {John C.} and Doubek, {Dennis L.} and Jean Chapuis and Robin Pettit and Schmidt, {Jean M.}",
year = "2005",
month = "5",
doi = "10.1021/np040203r",
language = "English (US)",
volume = "68",
pages = "729--733",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "5",

}

TY - JOUR

T1 - Antineoplastic agents. 534. Isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii

AU - Pettit, George

AU - Zhang, Qingwen

AU - Pinilla, Veronique

AU - Hoffmann, Holger

AU - Knight, John C.

AU - Doubek, Dennis L.

AU - Chapuis, Jean

AU - Pettit, Robin

AU - Schmidt, Jean M.

PY - 2005/5

Y1 - 2005/5

N2 - Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5% yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.

AB - Using bioactivity-directed isolation procedures, three new spirostanol saponins designated sansevierin A (1), sansevistatin 1 (2), and sansevistatin 2 (3) were isolated (10-5% yield) from the CH3OH-CH 2Cl2 extract of Sansevieria ehrenbergii, accompanied by three known steroidal saponins (4-6). The structures were determined on the basis of chemical methods and spectroscopic analysis, especially ID and 2D NMR experiments. Each of the saponins was evaluated against the P388 lymphocytic leukemia cell line and a panel of human cancer cell lines. Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans.

UR - http://www.scopus.com/inward/record.url?scp=20444488438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444488438&partnerID=8YFLogxK

U2 - 10.1021/np040203r

DO - 10.1021/np040203r

M3 - Article

C2 - 15921418

AN - SCOPUS:20444488438

VL - 68

SP - 729

EP - 733

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -