Antineoplastic agents. 529. Isolation and structure of nootkastatins 1 and 2 from the Alaskan yellow cedar Chamaecyparis nootkatensis

George Pettit, Rui Tan, Julian S. Northen, Delbert L. Herald, Jean Chapuis, Robin Pettit

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The yellow cedar tree, Chamaecyparis nootkatensis, collected in southeast Alaska was evaluated as a potential source of new anticancer agents. Two new diterpene anticancer constituents termed nootkastatins 1 (4) and 2 (5) were isolated along with three previously known diterpene cancer cell growth inhibitors where two were reported as synthetic modifications of totarol and not previously found in nature. All five diterpene structures were established by HRMS and 1D and 2D NMR spectroscopic analyses combined with three X-ray crystal structure determinations (2, 3, and 5). Against a panel of six human cancer cell lines, this series of diterpenes exhibited inhibition over the range GI 50 0.75-2.0 μg/mL, and all inhibited the growth of Gram-positive bacteria and fungi.

Original languageEnglish (US)
Pages (from-to)1476-1482
Number of pages7
JournalJournal of Natural Products
Volume67
Issue number9
DOIs
StatePublished - Sep 1 2004

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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