Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa

George Pettit, Jun-Ping Xu, Jean Chapuis, Robin Pettit, Larry P. Tackett, Dennis L. Doubek, John N A Hooper, Jean M. Schmidt

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to <0.0001 μg/mL) murine and human cancer cell growth inhibitors. Both were isolated (10-3-10 -4% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC, and ROESY) spectroscopy, revealed the unusual structures 1 and 2.

Original languageEnglish (US)
Pages (from-to)1149-1152
Number of pages4
JournalJournal of Medicinal Chemistry
Volume47
Issue number5
DOIs
StatePublished - Feb 26 2004

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Growth Inhibitors
Bioassay
Porifera
Antineoplastic Agents
Cells
Nuclear magnetic resonance
Spectroscopy
Biological Assay
Neoplasms
Spectrum Analysis
Cell Line
psymberin
irciniastatin B
APT
vitamin B 12 factor III

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa. / Pettit, George; Xu, Jun-Ping; Chapuis, Jean; Pettit, Robin; Tackett, Larry P.; Doubek, Dennis L.; Hooper, John N A; Schmidt, Jean M.

In: Journal of Medicinal Chemistry, Vol. 47, No. 5, 26.02.2004, p. 1149-1152.

Research output: Contribution to journalArticle

Pettit, George ; Xu, Jun-Ping ; Chapuis, Jean ; Pettit, Robin ; Tackett, Larry P. ; Doubek, Dennis L. ; Hooper, John N A ; Schmidt, Jean M. / Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa. In: Journal of Medicinal Chemistry. 2004 ; Vol. 47, No. 5. pp. 1149-1152.
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