Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa

George Pettit, Jun-Ping Xu, Jean Chapuis, Robin Pettit, Larry P. Tackett, Dennis L. Doubek, John N A Hooper, Jean M. Schmidt

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to <0.0001 μg/mL) murine and human cancer cell growth inhibitors. Both were isolated (10-3-10 -4% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC, and ROESY) spectroscopy, revealed the unusual structures 1 and 2.

Original languageEnglish (US)
Pages (from-to)1149-1152
Number of pages4
JournalJournal of Medicinal Chemistry
Volume47
Issue number5
DOIs
StatePublished - Feb 26 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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