Abstract
The Gulf of California shell-less mollusc Dolabella auricularia has been found to contain a new 14-membered macrocyclic lactone linked to a 2,4-di-O-methyl-L-α-rhamnopyranoside, designated dolastatin 19 (1). The new cancer cell growth inhibitor (1, 8.33 × 10-8% yield) was obtained by bioassay (P388 lymphocytic leukemia and human cancer cell lines) directed isolation, accompanied by debromoaplysiatoxin (9.17 × 10 -7% yield) and anhydrodebromoaplysiatoxin (2.0 × 10 -7% yield). The structures were determined on the basis of analyses of high-resolution mass spectra and high-field NMR data. All the relative stereochemistry for the chiral centers was designated by utilizing NMR techniques.
Original language | English (US) |
---|---|
Pages (from-to) | 1252-1255 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 67 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2004 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry