Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

George Pettit; Rui Tan; Delbert L. Herald; John Hamblin; Robin Pettit

doi:10.1021/np020144m

Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

George Pettit, Rui Tan, Delbert L. Herald, John Hamblin, Robin Pettit

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C₁₆-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.

Original language	English (US)
Pages (from-to)	276-278
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	2
DOIs	https://doi.org/10.1021/np020144m
State	Published - Feb 1 2003

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.",

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AU - Herald, Delbert L.

AU - Hamblin, John

AU - Pettit, Robin

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AB - Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.

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Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

Abstract

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