Abstract
Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 276-278 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 66 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2003 |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus. / Pettit, George; Tan, Rui; Herald, Delbert L.; Hamblin, John; Pettit, Robin.
In: Journal of Natural Products, Vol. 66, No. 2, 01.02.2003, p. 276-278.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus
AU - Pettit, George
AU - Tan, Rui
AU - Herald, Delbert L.
AU - Hamblin, John
AU - Pettit, Robin
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.
AB - Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037328682&partnerID=8YFLogxK
U2 - 10.1021/np020144m
DO - 10.1021/np020144m
M3 - Article
VL - 66
SP - 276
EP - 278
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 2
ER -