Abstract
Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 276-278 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 66 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2003 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Pettit, G., Tan, R., Herald, D. L., Hamblin, J., & Pettit, R. (2003). Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus. Journal of Natural Products, 66(2), 276-278. https://doi.org/10.1021/np020144m