Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

George Pettit, Rui Tan, Delbert L. Herald, John Hamblin, Robin Pettit

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.

Original languageEnglish (US)
Pages (from-to)276-278
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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