Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

George Pettit; Rui Tan; Delbert L. Herald; John Hamblin; Robin Pettit

doi:10.1021/np020144m

Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

George Pettit, Rui Tan, Delbert L. Herald, John Hamblin, Robin Pettit

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C₁₆-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.

Original language	English (US)
Pages (from-to)	276-278
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	2
DOIs	https://doi.org/10.1021/np020144m
State	Published - Feb 1 2003

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np020144m

Cite this

@article{f8ad8be6950a4eebbfb4839e5d913aab,

title = "Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus",

abstract = "Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.",

author = "George Pettit and Rui Tan and Herald, {Delbert L.} and John Hamblin and Robin Pettit",

year = "2003",

month = feb,

day = "1",

doi = "10.1021/np020144m",

language = "English (US)",

volume = "66",

pages = "276--278",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

AU - Pettit, George

AU - Tan, Rui

AU - Herald, Delbert L.

AU - Hamblin, John

AU - Pettit, Robin

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.

AB - Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C16-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271α isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an α-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.

UR - http://www.scopus.com/inward/record.url?scp=0037328682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037328682&partnerID=8YFLogxK

U2 - 10.1021/np020144m

DO - 10.1021/np020144m

M3 - Article

C2 - 12608865

AN - SCOPUS:0037328682

VL - 66

SP - 276

EP - 278

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 2

ER -

Antineoplastic agents. 488. Isolation and structure of yukonin from a Yukon Territory fungus

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this