Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.

George Pettit, Jeremiah C. Collins, John C. Knight, Delbert L. Herald, Ronald A. Nieman, Michael D. Williams, Robin Pettit

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED50 0.3 μg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) 15N, 1H, and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number4
DOIs
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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