Abstract
Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED50 0.3 μg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) 15N, 1H, and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.
Original language | English (US) |
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Pages (from-to) | 544-547 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 66 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2003 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Dive into the research topics of 'Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.'. Together they form a unique fingerprint.Datasets
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CCDC 212663: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Collins, J. C. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Nieman, R. A. (Creator), Williams, M. D. (Creator), Pettit, R. K. (Creator) & Pettit, G. R. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc7493r, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc7493r&sid=DataCite
Dataset