Abstract
Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED50 0.3 μg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) 15N, 1H, and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.
Original language | English (US) |
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Pages (from-to) | 544-547 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 66 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2003 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Dive into the research topics of 'Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.'. Together they form a unique fingerprint.Datasets
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CCDC 212663: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Collins, J. C. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Nieman, R. A. (Creator), Williams, M. D. (Creator) & Pettit, R. K. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc7493r, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc7493r&sid=DataCite
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