Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED50 0.3 μg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) 15N, 1H, and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Natural Products|
|State||Published - Apr 1 2003|
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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CCDC 212663: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Collins, J. C. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Nieman, R. A. (Creator), Williams, M. D. (Creator) & Pettit, R. K. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc7493r, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc7493r&sid=DataCite