Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.

George Pettit; Jeremiah C. Collins; John C. Knight; Delbert L. Herald; Ronald A. Nieman; Michael D. Williams; Robin Pettit

doi:10.1021/np020012t

Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.

George Pettit, Jeremiah C. Collins, John C. Knight, Delbert L. Herald, Ronald A. Nieman, Michael D. Williams, Robin Pettit

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED₅₀ 0.3 μg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) ¹⁵N, ¹H, and ¹³C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.

Original language	English (US)
Pages (from-to)	544-547
Number of pages	4
Journal	Journal of Natural Products
Volume	66
Issue number	4
DOIs	https://doi.org/10.1021/np020012t
State	Published - Apr 1 2003

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np020012t

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abstract = "Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED50 0.3 μg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) 15N, 1H, and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.",

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AU - Knight, John C.

AU - Herald, Delbert L.

AU - Nieman, Ronald A.

AU - Williams, Michael D.

AU - Pettit, Robin

PY - 2003/4/1

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AB - Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED50 0.3 μg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) 15N, 1H, and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.

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Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.

Abstract

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CCDC 212663: Experimental Crystal Structure Determination

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Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.

Abstract

ASJC Scopus subject areas

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CCDC 212663: Experimental Crystal Structure Determination

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