Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A

George Pettit, Sylvie Ducki, Delbert L. Herald, Dennis L. Doubek, Jean M. Schmidt, Jean Chapuis

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Two bromopyrrole marine alkaloids were isolated from the Mexican sponge, Agelas sp.: hymenidin (1) and agelastatin A (2). The structures were elucidated by analysis of their spectroscopic data and found to correspond to those in the literature. The absolute configuration of agelastatin A (2) was elucidated by single-crystal X-ray diffraction methods. Agelastatin A (2) exhibited strong activity against a panel of human cancer cell lines as well as human umbilical vein endothelial cells.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalOncology Research
Volume15
Issue number1
StatePublished - 2005

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Porifera
Antineoplastic Agents
Agelas
Human Umbilical Vein Endothelial Cells
Alkaloids
X-Ray Diffraction
Cell Line
agelastatin A
Neoplasms

Keywords

  • Agelastatin A
  • Anticancer
  • Hymenidin
  • Marine sponge

ASJC Scopus subject areas

  • Cancer Research

Cite this

Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A. / Pettit, George; Ducki, Sylvie; Herald, Delbert L.; Doubek, Dennis L.; Schmidt, Jean M.; Chapuis, Jean.

In: Oncology Research, Vol. 15, No. 1, 2005, p. 11-20.

Research output: Contribution to journalArticle

Pettit, George ; Ducki, Sylvie ; Herald, Delbert L. ; Doubek, Dennis L. ; Schmidt, Jean M. ; Chapuis, Jean. / Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A. In: Oncology Research. 2005 ; Vol. 15, No. 1. pp. 11-20.
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