Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A

George Pettit, Sylvie Ducki, Delbert L. Herald, Dennis L. Doubek, Jean M. Schmidt, Jean Chapuis

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Two bromopyrrole marine alkaloids were isolated from the Mexican sponge, Agelas sp.: hymenidin (1) and agelastatin A (2). The structures were elucidated by analysis of their spectroscopic data and found to correspond to those in the literature. The absolute configuration of agelastatin A (2) was elucidated by single-crystal X-ray diffraction methods. Agelastatin A (2) exhibited strong activity against a panel of human cancer cell lines as well as human umbilical vein endothelial cells.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalOncology Research
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Agelastatin A
  • Anticancer
  • Hymenidin
  • Marine sponge

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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