Abstract
Two bromopyrrole marine alkaloids were isolated from the Mexican sponge, Agelas sp.: hymenidin (1) and agelastatin A (2). The structures were elucidated by analysis of their spectroscopic data and found to correspond to those in the literature. The absolute configuration of agelastatin A (2) was elucidated by single-crystal X-ray diffraction methods. Agelastatin A (2) exhibited strong activity against a panel of human cancer cell lines as well as human umbilical vein endothelial cells.
Original language | English (US) |
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Pages (from-to) | 11-20 |
Number of pages | 10 |
Journal | Oncology Research |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - 2005 |
Keywords
- Agelastatin A
- Anticancer
- Hymenidin
- Marine sponge
ASJC Scopus subject areas
- General Medicine