Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine

George Pettit; Sylvie Ducki; Stephen A. Eastham; Noeleen Melody

doi:10.1021/np9001948

Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine

George Pettit, Sylvie Ducki, Stephen A. Eastham, Noeleen Melody

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

To further pursue the antineoplastic leads offered by our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-transdihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of these isocarbostyrils from narciclasine (2a) and 7-deoxynarciclasine (2c).

Original language	English (US)
Pages (from-to)	1279-1282
Number of pages	4
Journal	Journal of Natural Products
Volume	72
Issue number	7
DOIs	https://doi.org/10.1021/np9001948
State	Published - Jul 24 2009

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np9001948

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AU - Melody, Noeleen

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AB - To further pursue the antineoplastic leads offered by our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-transdihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of these isocarbostyrils from narciclasine (2a) and 7-deoxynarciclasine (2c).

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Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine

Abstract

ASJC Scopus subject areas

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