Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine

George Pettit, Sylvie Ducki, Stephen A. Eastham, Noeleen Melody

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

To further pursue the antineoplastic leads offered by our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-transdihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of these isocarbostyrils from narciclasine (2a) and 7-deoxynarciclasine (2c).

Original languageEnglish (US)
Pages (from-to)1279-1282
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number7
DOIs
StatePublished - Jul 24 2009

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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