Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina species

George Pettit; John C. Knight; Jeremiah C. Collins; Delbert L. Herald; Robin Pettit; Michael R. Boyd; Victor G. Young

doi:10.1021/np990618q

Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina species

George Pettit, John C. Knight, Jeremiah C. Collins, Delbert L. Herald, Robin Pettit, Michael R. Boyd, Victor G. Young

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10^-5 to 10^-7 % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) ¹H and ¹³C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 2² and the newly isolated cribrostatins 3-5 displayed antibacterial and/or antifungal activities.

Original language	English (US)
Pages (from-to)	793-798
Number of pages	6
Journal	Journal of Natural Products
Volume	63
Issue number	6
DOIs	https://doi.org/10.1021/np990618q
State	Published - Jun 2000

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np990618q

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title = "Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina species",

abstract = "Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10-5 to 10-7 % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) 1H and 13C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 22 and the newly isolated cribrostatins 3-5 displayed antibacterial and/or antifungal activities.",

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AU - Pettit, George

AU - Knight, John C.

AU - Collins, Jeremiah C.

AU - Herald, Delbert L.

AU - Pettit, Robin

AU - Boyd, Michael R.

AU - Young, Victor G.

PY - 2000/6

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N2 - Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10-5 to 10-7 % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) 1H and 13C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 22 and the newly isolated cribrostatins 3-5 displayed antibacterial and/or antifungal activities.

AB - Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10-5 to 10-7 % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) 1H and 13C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 22 and the newly isolated cribrostatins 3-5 displayed antibacterial and/or antifungal activities.

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Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina species

Abstract

ASJC Scopus subject areas

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