Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina species

George Pettit, John C. Knight, Jeremiah C. Collins, Delbert L. Herald, Robin Pettit, Michael R. Boyd, Victor G. Young

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10-5 to 10-7 % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) 1H and 13C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 22 and the newly isolated cribrostatins 3-5 displayed antibacterial and/or antifungal activities.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalJournal of Natural Products
Volume63
Issue number6
DOIs
StatePublished - Jun 2000

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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