Antineoplastic agents. 41. The beetle Allomyrina dichotomus

George Pettit, Richard H. Ode

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The Asian beetle Allomyrina dichotomus L. has been found to contain an antineoplastic agent. The substance responsible for this biological activity was located primarily in the beetle's legs and isolation guided by bioassay led to its characterization as a protein of at least 106 amino acid units. The protein was found to inhibit (64% at 3 mg/kg) growth of Walker intramuscular carcinosarcoma 256 in rats and was marginally active against P388 lymphocytic leukemia in mice.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalLloydia
Volume39
Issue number2-3
StatePublished - 1976

Fingerprint

antineoplastic agents
Beetles
Antineoplastic Agents
Walker Carcinoma 256
Coleoptera
Lymphoid Leukemia
lymphocytic leukemia
Bioassay
Bioactivity
Biological Assay
Rats
bioactive properties
Leg
legs
Proteins
proteins
bioassays
Amino Acids
amino acids
rats

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Medicine(all)

Cite this

Antineoplastic agents. 41. The beetle Allomyrina dichotomus. / Pettit, George; Ode, Richard H.

In: Lloydia, Vol. 39, No. 2-3, 1976, p. 129-133.

Research output: Contribution to journalArticle

Pettit, G & Ode, RH 1976, 'Antineoplastic agents. 41. The beetle Allomyrina dichotomus', Lloydia, vol. 39, no. 2-3, pp. 129-133.
Pettit, George ; Ode, Richard H. / Antineoplastic agents. 41. The beetle Allomyrina dichotomus. In: Lloydia. 1976 ; Vol. 39, No. 2-3. pp. 129-133.
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