Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19

George Pettit, Rui Tan, Jun-Ping Xu, Yoshitatsu Ichihara, Michael D. Williams, Michael R. Boyd

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50 < 10-3 μg/mL), and the U.S. National Cancer Institute's 60 human cancer cell line panel (mean panel GI50 ca. 10-9 M).

Original languageEnglish (US)
Pages (from-to)955-958
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number7
DOIs
StatePublished - Jul 1 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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