Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19

George Pettit; Rui Tan; Jun-Ping Xu; Yoshitatsu Ichihara; Michael D. Williams; Michael R. Boyd

doi:10.1021/np9800405

Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19

George Pettit, Rui Tan, Jun-Ping Xu, Yoshitatsu Ichihara, Michael D. Williams, Michael R. Boyd

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) ¹H, ¹³C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED₅₀ ca. 10^-3 μg/mL), a mini panel of human cancer cell lines (GI₅₀ < 10^-3 μg/mL), and the U.S. National Cancer Institute's 60 human cancer cell line panel (mean panel GI₅₀ ca. 10^-9 M).

Original language	English (US)
Pages (from-to)	955-958
Number of pages	4
Journal	Journal of Natural Products
Volume	61
Issue number	7
DOIs	https://doi.org/10.1021/np9800405
State	Published - Jul 1998

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50 < 10-3 μg/mL), and the U.S. National Cancer Institute's 60 human cancer cell line panel (mean panel GI50 ca. 10-9 M).",

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AU - Ichihara, Yoshitatsu

AU - Williams, Michael D.

AU - Boyd, Michael R.

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AB - Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50 < 10-3 μg/mL), and the U.S. National Cancer Institute's 60 human cancer cell line panel (mean panel GI50 ca. 10-9 M).

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Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19

Abstract

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