Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19

George Pettit, Rui Tan, Jun-Ping Xu, Yoshitatsu Ichihara, Michael D. Williams, Michael R. Boyd

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Continued investigation of murine leukemia (P-388) active fractions from the African marine worm Cephalodiscus gilchristi has resulted in the discovery of cephalostatins 18 (1b) and 19 (1c). The structures were determined by interpretation of their highfield (500 MHz) 1H, 13C, and 2D NMR and HRMS. Both of these new methoxy steroidal alkaloids exhibited strong activity against the murine P-388 lymphocytic leukemia cell line (ED50 ca. 10-3 μg/mL), a mini panel of human cancer cell lines (GI50 < 10-3 μg/mL), and the U.S. National Cancer Institute's 60 human cancer cell line panel (mean panel GI50 ca. 10-9 M).

Original languageEnglish (US)
Pages (from-to)955-958
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number7
DOIs
StatePublished - Jul 1998

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antineoplastic agents
Antineoplastic Agents
Cells
cell lines
Cell Line
Lymphoid Leukemia
lymphocytic leukemia
National Cancer Institute (U.S.)
mice
leukemia
Alkaloids
alkaloids
Neoplasms
Leukemia
Nuclear magnetic resonance
neoplasms
cephalostatin 19
cephalostatin 18
neoplasm cells

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19. / Pettit, George; Tan, Rui; Xu, Jun-Ping; Ichihara, Yoshitatsu; Williams, Michael D.; Boyd, Michael R.

In: Journal of Natural Products, Vol. 61, No. 7, 07.1998, p. 955-958.

Research output: Contribution to journalArticle

Pettit, George ; Tan, Rui ; Xu, Jun-Ping ; Ichihara, Yoshitatsu ; Williams, Michael D. ; Boyd, Michael R. / Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19. In: Journal of Natural Products. 1998 ; Vol. 61, No. 7. pp. 955-958.
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