Abstract
Bioassay-guided separation techniques were employed to isolate (3.3-10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1671-1677 |
| Number of pages | 7 |
| Journal | Collection of Czechoslovak Chemical Communications |
| Volume | 63 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1998 |
Keywords
- Crystal structure
- Marine sponge
- NMR spectroscopy
- Natural products
- Scalarolides
- Sesterterpenes
- Terpenes
- X-ray diffraction
ASJC Scopus subject areas
- Chemistry(all)
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Pettit, G., Cichacz, Z., Tan, R., Herald, D. L., Melody, N., Hoard, M. S., Doubek, D. L., & Hooper, J. N. A. (1998). Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta. Collection of Czechoslovak Chemical Communications, 63(10), 1671-1677. https://doi.org/10.1135/cccc19981671