Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

George Pettit, Zbigniew Cichacz, Rui Tan, Delbert L. Herald, Noeleen Melody, Michael S. Hoard, Dennis L. Doubek, John N A Hooper

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Bioassay-guided separation techniques were employed to isolate (3.3-10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

Original languageEnglish (US)
Pages (from-to)1671-1677
Number of pages7
JournalCollection of Czechoslovak Chemical Communications
Volume63
Issue number10
DOIs
StatePublished - Oct 1998

Keywords

  • Crystal structure
  • Marine sponge
  • NMR spectroscopy
  • Natural products
  • Scalarolides
  • Sesterterpenes
  • Terpenes
  • X-ray diffraction

ASJC Scopus subject areas

  • Chemistry(all)

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