Bioassay-guided separation techniques were employed to isolate (3.3-10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.
|Original language||English (US)|
|Number of pages||7|
|Journal||Collection of Czechoslovak Chemical Communications|
|State||Published - Oct 1998|
- Crystal structure
- Marine sponge
- NMR spectroscopy
- Natural products
- X-ray diffraction
ASJC Scopus subject areas
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Tan, R. (Contributor), Pettit, G. R. (Contributor), Doubek, D. L. (Contributor), Melody, N. (Contributor), Herald, D. L. (Contributor), Hooper, J. N. A. (Contributor), Cichacz, Z. A. (Contributor) & Hoard, M. S. (Contributor), The Cambridge Structural Database, Jan 1 2000