Abstract
Bioassay-guided separation techniques were employed to isolate (3.3-10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.
Original language | English (US) |
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Pages (from-to) | 1671-1677 |
Number of pages | 7 |
Journal | Collection of Czechoslovak Chemical Communications |
Volume | 63 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1998 |
Keywords
- Crystal structure
- Marine sponge
- NMR spectroscopy
- Natural products
- Scalarolides
- Sesterterpenes
- Terpenes
- X-ray diffraction
ASJC Scopus subject areas
- Chemistry(all)