Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

George Pettit; Zbigniew Cichacz; Rui Tan; Delbert L. Herald; Noeleen Melody; Michael S. Hoard; Dennis L. Doubek; John N A Hooper

doi:10.1135/cccc19981671

Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

George Pettit, Zbigniew Cichacz, Rui Tan, Delbert L. Herald, Noeleen Melody, Michael S. Hoard, Dennis L. Doubek, John N A Hooper

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Bioassay-guided separation techniques were employed to isolate (3.3-10^-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED₅₀ 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

Original language	English (US)
Pages (from-to)	1671-1677
Number of pages	7
Journal	Collection of Czechoslovak Chemical Communications
Volume	63
Issue number	10
DOIs	https://doi.org/10.1135/cccc19981671
State	Published - Oct 1998

Keywords

Crystal structure
Marine sponge
NMR spectroscopy
Natural products
Scalarolides
Sesterterpenes
Terpenes
X-ray diffraction

ASJC Scopus subject areas

Chemistry(all)

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10.1135/cccc19981671

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Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta. / Pettit, George; Cichacz, Zbigniew; Tan, Rui; Herald, Delbert L.; Melody, Noeleen; Hoard, Michael S.; Doubek, Dennis L.; Hooper, John N A.

In: Collection of Czechoslovak Chemical Communications, Vol. 63, No. 10, 10.1998, p. 1671-1677.

Research output: Contribution to journal › Article › peer-review

Pettit, George ; Cichacz, Zbigniew ; Tan, Rui ; Herald, Delbert L. ; Melody, Noeleen ; Hoard, Michael S. ; Doubek, Dennis L. ; Hooper, John N A. / Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta. In: Collection of Czechoslovak Chemical Communications. 1998 ; Vol. 63, No. 10. pp. 1671-1677.

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Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

Abstract

Keywords

ASJC Scopus subject areas

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