Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18

George Pettit, Feng Gao, Peter M. Blumberg, Cherry L. Herald, John C. Coll, Yoshiaki Kamano, Nancy E. Lewin, Jean M. Schmidt, Jean Chapuis

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Separation of two trace cancer cell growth inhibitory (P388 leukemia) fractions from about 1000 kg of wet Gulf of Mexico Bugula neritina (Bryozoa) has led to the isolation of bryostatins 16-18 (2-4). A combination of HRFABMS and high-field (400 MHz) 1H- and 13C-NMR spectral analyses were employed to assign the structures. The three new 20-desoxybryostatins 16 (2), 17 (3), and 18 (4) showed significant growth inhibitory activity (P388 ED50, 2, 9.3 x 10-3 μg/mL, 3, 1.9 x 10-2 μg/mL, and 4, 3.3 x 10-3 μg/mL) against murine P388 lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)286-289
Number of pages4
JournalJournal of Natural Products
Volume59
Issue number3
DOIs
StatePublished - Mar 1996

Fingerprint

bryostatins
lymphocytic leukemia
antineoplastic agents
Bryozoa
Cell growth
Gulf of Mexico
leukemia
Antineoplastic Agents
cell growth
Nuclear magnetic resonance
Leukemia P388
Lymphoid Leukemia
mice
Growth
Neoplasms
neoplasm cells
bryostatin 16
bryostatin 18

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18. / Pettit, George; Gao, Feng; Blumberg, Peter M.; Herald, Cherry L.; Coll, John C.; Kamano, Yoshiaki; Lewin, Nancy E.; Schmidt, Jean M.; Chapuis, Jean.

In: Journal of Natural Products, Vol. 59, No. 3, 03.1996, p. 286-289.

Research output: Contribution to journalArticle

Pettit, G, Gao, F, Blumberg, PM, Herald, CL, Coll, JC, Kamano, Y, Lewin, NE, Schmidt, JM & Chapuis, J 1996, 'Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18', Journal of Natural Products, vol. 59, no. 3, pp. 286-289. https://doi.org/10.1021/np960100b
Pettit, George ; Gao, Feng ; Blumberg, Peter M. ; Herald, Cherry L. ; Coll, John C. ; Kamano, Yoshiaki ; Lewin, Nancy E. ; Schmidt, Jean M. ; Chapuis, Jean. / Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18. In: Journal of Natural Products. 1996 ; Vol. 59, No. 3. pp. 286-289.
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