Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18

George Pettit; Feng Gao; Peter M. Blumberg; Cherry L. Herald; John C. Coll; Yoshiaki Kamano; Nancy E. Lewin; Jean M. Schmidt; Jean Chapuis

doi:10.1021/np960100b

Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18

George Pettit, Feng Gao, Peter M. Blumberg, Cherry L. Herald, John C. Coll, Yoshiaki Kamano, Nancy E. Lewin, Jean M. Schmidt, Jean Chapuis

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64 Scopus citations

Abstract

Separation of two trace cancer cell growth inhibitory (P388 leukemia) fractions from about 1000 kg of wet Gulf of Mexico Bugula neritina (Bryozoa) has led to the isolation of bryostatins 16-18 (2-4). A combination of HRFABMS and high-field (400 MHz) ¹H- and ¹³C-NMR spectral analyses were employed to assign the structures. The three new 20-desoxybryostatins 16 (2), 17 (3), and 18 (4) showed significant growth inhibitory activity (P388 ED₅₀, 2, 9.3 x 10^-3 μg/mL, 3, 1.9 x 10^-2 μg/mL, and 4, 3.3 x 10^-3 μg/mL) against murine P388 lymphocytic leukemia.

Original language	English (US)
Pages (from-to)	286-289
Number of pages	4
Journal	Journal of Natural Products
Volume	59
Issue number	3
DOIs	https://doi.org/10.1021/np960100b
State	Published - Mar 1996

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np960100b

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title = "Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18",

abstract = "Separation of two trace cancer cell growth inhibitory (P388 leukemia) fractions from about 1000 kg of wet Gulf of Mexico Bugula neritina (Bryozoa) has led to the isolation of bryostatins 16-18 (2-4). A combination of HRFABMS and high-field (400 MHz) 1H- and 13C-NMR spectral analyses were employed to assign the structures. The three new 20-desoxybryostatins 16 (2), 17 (3), and 18 (4) showed significant growth inhibitory activity (P388 ED50, 2, 9.3 x 10-3 μg/mL, 3, 1.9 x 10-2 μg/mL, and 4, 3.3 x 10-3 μg/mL) against murine P388 lymphocytic leukemia.",

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AU - Pettit, George

AU - Gao, Feng

AU - Blumberg, Peter M.

AU - Herald, Cherry L.

AU - Coll, John C.

AU - Kamano, Yoshiaki

AU - Lewin, Nancy E.

AU - Schmidt, Jean M.

AU - Chapuis, Jean

PY - 1996/3

Y1 - 1996/3

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AB - Separation of two trace cancer cell growth inhibitory (P388 leukemia) fractions from about 1000 kg of wet Gulf of Mexico Bugula neritina (Bryozoa) has led to the isolation of bryostatins 16-18 (2-4). A combination of HRFABMS and high-field (400 MHz) 1H- and 13C-NMR spectral analyses were employed to assign the structures. The three new 20-desoxybryostatins 16 (2), 17 (3), and 18 (4) showed significant growth inhibitory activity (P388 ED50, 2, 9.3 x 10-3 μg/mL, 3, 1.9 x 10-2 μg/mL, and 4, 3.3 x 10-3 μg/mL) against murine P388 lymphocytic leukemia.

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Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18

Abstract

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