Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae)

George Pettit, Michael S. Hoard, Dennis L. Doubek, Jean M. Schmidt, Robin Pettit, Larry P. Tackett, Jean Chapuis

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

By means of bioassay-guided separation methods, the cancer cell growth inhibitory constituents residing in the bark, stem and leaves of the Mauritius medicinal plant Terminalia arjuna (Combretaceae) were examined. The cancer cell line active components were found to be gallic acid, ethyl gallate, and the flavone luteolin. Only gallic acid was previously known to occur in this plant. Luteolin has a well established record of inhibiting various cancer cell lines and may account for most of the rationale underlying the use of T. arjuna in traditional cancer treatments. Luteolin was also found to exhibit specific activity against the pathogenic bacterium Neisseria gonorrhoeae.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalJournal of Ethnopharmacology
Volume53
Issue number2
DOIs
StatePublished - Aug 1996

Keywords

  • Cancer
  • Luteolin
  • Neisseria

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Pettit, G., Hoard, M. S., Doubek, D. L., Schmidt, J. M., Pettit, R., Tackett, L. P., & Chapuis, J. (1996). Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae). Journal of Ethnopharmacology, 53(2), 57-63. https://doi.org/10.1016/0378-8741(96)01421-3