Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae)

George Pettit; Michael S. Hoard; Dennis L. Doubek; Jean M. Schmidt; Robin Pettit; Larry P. Tackett; Jean Chapuis

doi:10.1016/0378-8741(96)01421-3

Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae)

George Pettit, Michael S. Hoard, Dennis L. Doubek, Jean M. Schmidt, Robin Pettit, Larry P. Tackett, Jean Chapuis

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

By means of bioassay-guided separation methods, the cancer cell growth inhibitory constituents residing in the bark, stem and leaves of the Mauritius medicinal plant Terminalia arjuna (Combretaceae) were examined. The cancer cell line active components were found to be gallic acid, ethyl gallate, and the flavone luteolin. Only gallic acid was previously known to occur in this plant. Luteolin has a well established record of inhibiting various cancer cell lines and may account for most of the rationale underlying the use of T. arjuna in traditional cancer treatments. Luteolin was also found to exhibit specific activity against the pathogenic bacterium Neisseria gonorrhoeae.

Original language	English (US)
Pages (from-to)	57-63
Number of pages	7
Journal	Journal of Ethnopharmacology
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/0378-8741(96)01421-3
State	Published - Aug 1996

Keywords

Cancer
Luteolin
Neisseria

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/0378-8741(96)01421-3

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title = "Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae)",

abstract = "By means of bioassay-guided separation methods, the cancer cell growth inhibitory constituents residing in the bark, stem and leaves of the Mauritius medicinal plant Terminalia arjuna (Combretaceae) were examined. The cancer cell line active components were found to be gallic acid, ethyl gallate, and the flavone luteolin. Only gallic acid was previously known to occur in this plant. Luteolin has a well established record of inhibiting various cancer cell lines and may account for most of the rationale underlying the use of T. arjuna in traditional cancer treatments. Luteolin was also found to exhibit specific activity against the pathogenic bacterium Neisseria gonorrhoeae.",

keywords = "Cancer, Luteolin, Neisseria",

author = "George Pettit and Hoard, {Michael S.} and Doubek, {Dennis L.} and Schmidt, {Jean M.} and Robin Pettit and Tackett, {Larry P.} and Jean Chapuis",

note = "Funding Information: We are pleased to thank the following for the important financial support: Outstanding Investigator Grant CA44344-01A1-01-6 awarded by the Division of Cancer Treatment, National",

year = "1996",

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doi = "10.1016/0378-8741(96)01421-3",

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T1 - Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae)

AU - Pettit, George

AU - Hoard, Michael S.

AU - Doubek, Dennis L.

AU - Schmidt, Jean M.

AU - Pettit, Robin

AU - Tackett, Larry P.

AU - Chapuis, Jean

N1 - Funding Information: We are pleased to thank the following for the important financial support: Outstanding Investigator Grant CA44344-01A1-01-6 awarded by the Division of Cancer Treatment, National

PY - 1996/8

Y1 - 1996/8

N2 - By means of bioassay-guided separation methods, the cancer cell growth inhibitory constituents residing in the bark, stem and leaves of the Mauritius medicinal plant Terminalia arjuna (Combretaceae) were examined. The cancer cell line active components were found to be gallic acid, ethyl gallate, and the flavone luteolin. Only gallic acid was previously known to occur in this plant. Luteolin has a well established record of inhibiting various cancer cell lines and may account for most of the rationale underlying the use of T. arjuna in traditional cancer treatments. Luteolin was also found to exhibit specific activity against the pathogenic bacterium Neisseria gonorrhoeae.

AB - By means of bioassay-guided separation methods, the cancer cell growth inhibitory constituents residing in the bark, stem and leaves of the Mauritius medicinal plant Terminalia arjuna (Combretaceae) were examined. The cancer cell line active components were found to be gallic acid, ethyl gallate, and the flavone luteolin. Only gallic acid was previously known to occur in this plant. Luteolin has a well established record of inhibiting various cancer cell lines and may account for most of the rationale underlying the use of T. arjuna in traditional cancer treatments. Luteolin was also found to exhibit specific activity against the pathogenic bacterium Neisseria gonorrhoeae.

KW - Cancer

KW - Luteolin

KW - Neisseria

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ER -

Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae)

Abstract

Keywords

ASJC Scopus subject areas

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